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All about: Angiomax

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Generic Name: Bivalirudin Injection (bye-VAL-ih-ruh-din)
Brand Name: Angiomax

Angiomax is used for:

Thinning the blood in patients with unstable angina who are undergoing percutaneous transluminal coronary angioplasty (PTCA) and in patients undergoing percutaneous coronary intervention (PCI). Angiomax is used in conjunction with other medicines. It may also be used for other conditions as determined by your doctor.

Angiomax is a thrombin inhibitor. It works by blocking the formation of blood clots.

Do NOT use Angiomax if:

  • you are allergic to any ingredient in Angiomax
  • you have active major bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Angiomax :

Some medical conditions may interact with Angiomax . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of blood clots or bleeding problems (eg, hemophilia)

Some MEDICINES MAY INTERACT with Angiomax . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin, heparin), glycoprotein IIb/IIIa inhibitors (eg, abciximab), platelet inhibitors (eg, cilostazol), or thrombolytics (eg, alteplase) because the risk of serious side effects, such as bleeding, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Angiomax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Angiomax :

Use Angiomax as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Angiomax is administered as an injection at your doctor's office, hospital, or clinic.
  • If you miss a dose of Angiomax , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Angiomax .

Important safety information:

  • Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Angiomax . Using Angiomax alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • This medicine reduces the ability of the blood to clot. To prevent bleeding, avoid situations in which bruising or injury may occur.
  • LAB TESTS, including blood clotting tests and blood pressure, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Angiomax with caution in the ELDERLY because they may be more sensitive to its effects, such as bleeding.
  • Use Angiomax with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • If you become pregnant, discuss with your doctor the benefits and risks of using Angiomax during pregnancy. It is unknown if Angiomax is excreted in breast milk. If you are or will be breast-feeding, discuss with your doctor the risks to your baby.

Possible side effects of Angiomax :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; back, stomach, or pelvic pain; headache; nausea; nervousness; pain at the injection site; trouble sleeping; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); calf pain or tenderness; chest pain or tightness; confusion; difficulty urinating; dizziness; easy bruising or bleeding; fainting; fast, slow, or irregular heartbeat; fever; loss of consciousness; one-sided weakness; paralysis of the face; severe bleeding; shortness of breath; vision or speech changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include bleeding.

Proper storage of Angiomax :

Angiomax is usually handled and stored by a health care provider. If you are using Angiomax at home, store Angiomax as directed by your pharmacist or health care provider. Keep Angiomax out of the reach of children and away from pets.

General information:

  • If you have any questions about Angiomax , please talk with your doctor, pharmacist, or other health care provider.
  • Angiomax is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Angiomax . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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