18 . July , 2018 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Anidulafungin

Big Image Pronouncation: (AN-ih-doo-la-FUN-jin)
Class: Antifungal

Trade Names:
Eraxis
- Powder for injection, lyophilized 50 mg

Mechanism of Action

Pharmacology

Inhibits formation of an essential component of fungal cell walls by inhibiting glucan synthase, an enzyme present in fungal cells.

Pharmacokinetics

Absorption

C max ranges from 3.55 to 10.9 mg/L; AUC ranges from 42.3 to 168.9 mg•h/L.

Distribution

Vd is 30 to 50 L. Protein binding is 84%.

Metabolism

Undergoes slow chemical degradation at physiologic temperature and pH. Anidulafungin is not a substrate, inducer, or inhibitor of CYP isozymes.

Elimination

Cl is 0.84 to 0.78 L/h; t ½ is 43.2 to 50.3 h. Approximately 30% excreted in feces over 9 days and less than 1% excreted in urine.

Special Populations

Renal Function Impairment

Dosage adjustments are not necessary based on degree of renal insufficiency, including hemodialysis.

Hepatic Function Impairment

Dosage adjustment not necessary based on mild, moderate, or severe hepatic insufficiency.

Elderly

Dosage adjustments not necessary for elderly patients.

Gender

Dosage adjustments not necessary based on gender.

Race

Dosage adjustments not necessary based on race.

HIV status

Dosage adjustments not necessary based on HIV status, including coadministration of antiretroviral therapy.

Indications and Usage

Treatment of esophageal candidiasis, candidemia, and other forms of Candida infections.

Contraindications

Hypersensitivity to echinocandins or any component of the product.

Dosage and Administration

Candidemia or other Candida Infections
Adults

IV Single 200 mg loading dose on day 1 followed by 100 mg/day thereafter, generally for at least 14 days after the last positive culture.

Esophageal Candidiasis
Adults

IV Single 100 mg loading dose on day 1 followed by 50 mg/day thereafter for a minimum of 14 days or at least 7 days following resolution of symptoms.

General Advice

  • For IV infusion, not for IV bolus injection.
  • Only reconstitute with companion diluent (20% [w/w] dehydrated alcohol in water for injection) and subsequently dilute only with dextrose 5% injection or sodium chloride 0.9% injection.
  • Reconstitute each 50 mg vial with 15 mL of companion diluent to a concentration of 3.33 mg/mL.
  • Aseptically transfer the contents of the reconstituted vial(s) into an IV bag (or bottle) containing dextrose 5% injection or sodium chloride 0.9% injection (normal saline) to provide an infusion solution concentration of 0.5 mg/mL.
  • Rate of infusion should not exceed 1.1 mg/min.
  • Do not administer if particulate matter or discoloration noted.

Storage/Stability

Store unreconstituted vials and companion vials at 77°F; excursions permitted to 59° to 86°F. Do not freeze.

Store reconstituted solution at 77°F; excursions permitted to 59° to 86°F. Do not freeze. The reconstituted solution must be further diluted to an infusion solution and administered within 24 h.

Store the infusion solution at 77°F; excursions permitted to 59° to 86°F.

Drug Interactions

Cyclosporine

Anidulafungin AUC may be slightly increased.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Atrial fibrillation, hypertension, hypotension, right bundle branch block, sinus arrhythmia, superficial thrombophlebitis, ventricular extrasystoles (less than 2%).

CNS

Headache (1%); convulsions, dizziness (less than 2%).

Dermatologic

Rash (1%); angioneurotic edema, erythema, flushing, increased sweating, pruritus, urticaria (less than 2%).

EENT

Blurred vision, eye pain, visual disturbance (less than 2%).

GI

Diarrhea (3%); constipation, diarrhea NOS, dyspepsia, fecal incontinence, upper abdominal pain (less than 2%); nausea, vomiting (1%).

Hematologic-Lymphatic

Deep vein thrombosis, leukopenia, neutropenia (1%); coagulopathy, thrombocytopenia (less than 2%).

Hepatic

Cholestasis, hepatic necrosis (less than 2%).

Lab Tests

Decreased potassium (3%); increased ALT (2%); increased alkaline phosphatase, increased hepatic enzyme (2%); increased AST, increased gamma-glutamyl transferase (1%); decreased magnesium and platelet count, increased amylase, bilirubin, calcium, CPK, creatinine, lipase, magnesium, platelet count, sodium and urea, PT prolongation, QT prolongation (less than 2%).

Local

Infusion-related reaction, peripheral edema, rigors (less than 2%).

Metabolic-Nutritional

Hyperglycemia (less than 2%).

Musculoskeletal

Back pain (less than 2%).

Respiratory

Cough (less than 2%).

Miscellaneous

Candidiasis, clostridial infection, fungemia, oral candidiasis (less than 2%).

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established.

Hepatic Function

Monitor patients developing abnormal LFTs during use of anidulafungin for worsening hepatic function and evaluate for continued therapy.

Overdosage

Symptoms

Generally well tolerated. Transient, asymptomatic transaminase elevations have been reported.

Recent Drug Updates at DrugIndexOnline:





Buprenorphine Hydrochloride/Naloxone Hydrochloride Buprenorphine Hydrochloride/Naloxone Hydrochloride
Pronouncation: (BYOO-preh-NAHR-feen HIGH-droe-KLOR-ide/NAL-ox-ohn HIGH-droe-KLOR-ide) Class: Narcotic agonist-antagonist analgesic Trade Names: Suboxone - Tablets, sublingual 2 mg buprenorphine base per 0.5 mg naloxone - Tablets, sublingual 8 mg buprenorphine base per 2 mg naloxone Mechanism of Act more...

caffeine citrate caffeine citrate
Generic Name: caffeine citrate (oral) (KAF een SIT rate) Brand Names: Cafcit What is this drug? Caffeine citrate is a central nervous system stimulant. It also has effects on the lungs and metabolism. Caffeine citrate is used to treat breathing problems in premature infants. Caffeine ci more...

Docusate Rectal Docusate Rectal
Some commonly used brand names are: In the U.S.— Bisco-Lax 1 Ceo-Two 5 Dacodyl 1 Deficol 1 Dulcolax 1 Fleet Babylax 3 Fleet Bisacodyl 1 Fleet Enema 7 Fleet Enema for Children 7 Fleet Enema Mineral Oil 4 Fleet Glycerin Laxative 3 Fleet Laxative 1 Sani-Supp 3 Senokot 6 Theralax 1 Therevac P more...

Econopred Plus Econopred Plus
Generic Name: prednisolone acetate Dosage Form: 1% ophthalmic suspension DESCRIPTION ECONOPRED® Plus (prednisolone acetate ophthalmic suspension) is a adrenocortical steroid products prepared as sterile ophthalmic suspension. The active ingredient is represented by the chemical structure: more...

Ioxaglate Diagnostic Ioxaglate Diagnostic
This information applies to the following medicines: 1. Diatrizoates (dye-a-tri-ZOE-ates) 2. Iodipamide (eye-oh-DI-pa-mide) 3. Iohexol (eye-oh-HEX-ole) 4. Iopamidol (eye-oh-PA-mi-dole) 5. Iothalamate (eye-oh-thal-A-mate) 6. Ioversol (eye-oh-VER-sole) 7. Ioxaglate (eye-OX-a-glate) more...

Phrenilin Phrenilin
Generic Name: butalbital and acetaminophen Dosage Form: Capsules Phrenilin Description Phrenilin®: Each Phrenilin® tablet for oral administration, contains Butalbital, USP 50 mg, Acetaminophen, USP 325 mg. In addition each Phrenilin® tablet contains the following inactive ingredients: more...

Piloptic-½ Ophthalmic Piloptic-½ Ophthalmic
Some commonly used brand names are: In the U.S.— Adsorbocarpine Akarpine Isopto Carpine Ocu-Carpine Ocusert Pilo-20 Ocusert Pilo-40 Pilagan Pilocar Pilopine HS Piloptic-1/2 Piloptic-1 Piloptic-2 Piloptic-3 Piloptic-4 Piloptic-6 Pilostat In Canada— Isopto Carpine Minims Pilocarpine more...

Poly-Vi-Flor with Iron Poly-Vi-Flor with Iron
Generic Name: multivitamin with iron and fluoride (mul tee VY ta min with EYE urn and FLOOR ide) Brand Names: Multi Vita Bets and Fluoride and Iron, Poly-Vi-Flor with Iron, Tri-Vi-Flor with Iron, Vi-Daylin/F Plus Iron What is Poly-Vi-Flor with Iron (multivitamin with iron and fl more...