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All about: Noxafil

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Generic Name: posaconazole (poe sa KONE a zole)
Brand Names: Noxafil

What is posaconazole?

Posaconazole is an antifungal antibiotic that fights certain infections cause by fungus.

Posaconazole is used to prevent fungal infections in people with weak immune systems resulting from chemotherapy or stem cell transplantation.

Posaconazole may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about posaconazole?

Do not use this medication if you are allergic to posaconazole, or if you are using any of the following drugs:
  • astemizole (Hismanal);

  • cisapride (Propulsid);

  • halofantrine (Halfan);

  • pimozide (Orap);

  • quinidine (Cardioquin, Quinidex, Quinaglute); or

  • terfenadine (Seldane); or

  • ergot medicine such as methysergide (Sansert), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), methylergonovine (Methergine).

Take posaconazole for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Posaconazole will not treat a viral infection such as the common cold or flu.

What should I discuss with my healthcare provider before using posaconazole?

Do not use this medication if you are allergic to posaconazole, or if you are using any of the following drugs:
  • astemizole (Hismanal);

  • cisapride (Propulsid);

  • halofantrine (Halfan);

  • pimozide (Orap);

  • quinidine (Cardioquin, Quinidex, Quinaglute); or

  • terfenadine (Seldane); or

  • ergot medicine such as methysergide (Sansert), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), methylergonovine (Methergine).

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have:

  • a personal or family history of "Long QT syndrome";

  • a history of allergy to antibiotics such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

  • liver disease; or

  • a heart rhythm disorder.

If you have any of these conditions, you may not be able to use posaconazole, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether posaconazole passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 13 years old.

How should I take posaconazole?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Posaconazole works best if you take it with a full meal or a nutritional supplement (such as Ensure).

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Posaconazole will not treat a viral infection such as the common cold or flu. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Store posaconazole at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a posaconazole overdose are not known.

What should I avoid while taking posaconazole?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Posaconazole side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • easy bruising or bleeding, unusual weakness;

  • fever, chills, cough, body aches, flu symptoms;

  • fast heart rate;

  • feeling light-headed, fainting;

  • dry mouth, increased thirst, drowsiness, restless feeling, confusion, nausea, vomiting, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting, or seizure (convulsions);

  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

  • swelling of your ankles or feet;

  • white patches or sores inside your mouth or on your lips;

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • diarrhea that is watery or bloody.

Less serious side effects are more likely to occur, such as:

  • tired feeling;

  • joint or muscle pain;

  • sleep problems (insomnia);

  • headache, dizziness;

  • mild nausea, vomiting, diarrhea, constipation, or stomach pain; or

  • skin rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect posaconazole?

Before taking posaconazole, tell your doctor if you are using any of the following drugs:

  • cimetidine (Tagamet);

  • cyclosporine (Neoral, Sandimmune, Gengraf);

  • midazolam (Versed);

  • phenytoin (Dilantin);

  • rifabutin (Mycobutin);

  • sirolimus (Rapamune) or tacrolimus (Prograf);

  • cancer medicines such as vinblastine (Velban) or vincristine (Oncovin, Vincasar), vindesine (Eldisine), or vinorelbine (Navelbine);

  • a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan); or

  • cholesterol-lowering medicines such as lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor), or cerivastatin (Baycol).

If you are using any of these drugs, you may not be able to use posaconazole, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect posaconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has information about posaconazole written for health professionals that you may read.

What does my medication look like?

Posaconazole is available with a prescription under the brand name Noxafil. Other brand or generic forms may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Noxafil 40 mg/mL--in 4-ounce amber glass bottle

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.01. Revision Date: 9/27/06 3:46:31 PM.

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