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All about: Omeprazole/Sodium Bicarbonate

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Generic Name: Omeprazole/Sodium Bicarbonate Capsules (oh-MEP-ra-zole/SOE-dee-um bye-KAR-bo-nate)
Brand Name: Zegerid

Omeprazole/Sodium Bicarbonate is used for:

Treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may be used for short-term treatment of ulcers of the stomach or small intestines. It may be used to decrease the risk of stomach bleeding in severely ill patients. It may also be used for other conditions as determined by your doctor.

Omeprazole/Sodium Bicarbonate is a proton pump inhibitor (PPI) and sodium bicarbonate combination. The PPI works by decreasing the amount of acid produced in the stomach. The sodium bicarbonate slows the breakdown of the PPI in the stomach, which helps to increase absorption of the PPI.

Do NOT use Omeprazole/Sodium Bicarbonate if:

  • you are allergic to any ingredient in Omeprazole/Sodium Bicarbonate
  • you have low blood calcium levels or metabolic alkalosis
  • you are taking an HIV protease inhibitor (eg, atazanavir)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Omeprazole/Sodium Bicarbonate :

Some medical conditions may interact with Omeprazole/Sodium Bicarbonate . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver problems, stomach or bowel cancer, or undiagnosed bleeding from the rectum
  • if you have Bartter syndrome, low blood potassium levels, acid-base balance problems, or respiratory alkalosis

Some MEDICINES MAY INTERACT with Omeprazole/Sodium Bicarbonate . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Clarithromycin or voriconazole because they may increase the risk of Omeprazole/Sodium Bicarbonate 's side effects
  • Anticoagulants (eg, warfarin), benzodiazepines (eg, diazepam), cilostazol, cyclosporine, digoxin, disulfiram, phenytoin, or tacrolimus because the risk of their side effects may be increased by Omeprazole/Sodium Bicarbonate
  • Ampicillins, azole antifungals (eg, ketoconazole), ginkgo biloba, HIV protease inhibitors (eg, atazanavir), or iron because their effectiveness may be decreased by Omeprazole/Sodium Bicarbonate

This may not be a complete list of all interactions that may occur. Ask your health care provider if Omeprazole/Sodium Bicarbonate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Omeprazole/Sodium Bicarbonate :

Use Omeprazole/Sodium Bicarbonate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Omeprazole/Sodium Bicarbonate by mouth on an empty stomach at least 1 hour before a eating.
  • Take Omeprazole/Sodium Bicarbonate with a full glass of water (8 oz/240 mL). Do not take Omeprazole/Sodium Bicarbonate with other liquids.
  • Swallow Omeprazole/Sodium Bicarbonate whole. Do not break, crush, or chew before swallowing. Do not open the capsule and sprinkle the contents on food.
  • If you also take an imidazole antifungal (eg, ketoconazole), take it at least 2 hours before taking Omeprazole/Sodium Bicarbonate .
  • If you also take sucralfate, take his medicine at least 30 minutes before taking sucralfate.
  • You may take antacids while you are using Omeprazole/Sodium Bicarbonate if you are directed to do so by your doctor.
  • Continue to take Omeprazole/Sodium Bicarbonate even if you feel well. Do not miss any doses.
  • If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Omeprazole/Sodium Bicarbonate .

Important safety information:

  • Omeprazole/Sodium Bicarbonate may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Omeprazole/Sodium Bicarbonate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Contact your doctor if you have any signs of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds; or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.
  • Omeprazole/Sodium Bicarbonate has sodium in it. Include this when you count your daily intake of sodium.
  • Long-term use of Omeprazole/Sodium Bicarbonate with calcium or milk may cause milk-alkali syndrome. Check with your doctor before taking calcium supplements, antacids that contain calcium, or drinking milk while you are taking Omeprazole/Sodium Bicarbonate .
  • Both strengths of Omeprazole/Sodium Bicarbonate contain the same amount of sodium bicarbonate. Therefore, if your doctor has prescribed the 40 mg dose, do not take 2 of the 20 mg capsules to make a 40 mg dose.
  • Omeprazole/Sodium Bicarbonate may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Omeprazole/Sodium Bicarbonate .
  • Omeprazole/Sodium Bicarbonate should be used with extreme caution in Asian patients; the risk of side effects may be increased in these patients.
  • Omeprazole/Sodium Bicarbonate should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Omeprazole/Sodium Bicarbonate while you are pregnant. Omeprazole/Sodium Bicarbonate is found in breast milk. Do not breast-feed while taking Omeprazole/Sodium Bicarbonate .

Possible side effects of Omeprazole/Sodium Bicarbonate :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain, dark urine, fast or irregular heartbeat; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; seizures; swelling of the hands, ankles, or feet; unusual bruising or bleeding; unusual or sudden weight increase; unusual tiredness; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; confusion; fast heartbeat; flushing; increased sweating; seizures; severe headache, drowsiness, or nausea; vomiting.

Proper storage of Omeprazole/Sodium Bicarbonate :

Store Omeprazole/Sodium Bicarbonate at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Omeprazole/Sodium Bicarbonate out of the reach of children and away from pets.

General information:

  • If you have any questions about Omeprazole/Sodium Bicarbonate , please talk with your doctor, pharmacist, or other health care provider.
  • Omeprazole/Sodium Bicarbonate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Omeprazole/Sodium Bicarbonate . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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