19 . October , 2018 - Friday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Pegfilgrastim

Big Image Pronouncation: (peg-fill-GRAH-stim)
Class: Colony-stimulating factor

Trade Names:
- Solution for injection 10 mg/mL

Mechanism of Action


Stimulates neutrophil production within bone marrow.



T 1/ 2 is 15 to 80 hr (SC injection). Serum clearance is directly related to the number of neutrophils.

Indications and Usage

Decrease incidence of infection, manifested by febrile neutropenia, in patients with nonmyeloid malignancies receiving myelosuppressive anticancer drugs associated with febrile neutropenia.


Hypersensitivity to Escherichia coli -derived proteins, filgrastim, pegfilgrastim, or any component of the product.

Dosage and Administration


SC 6 mg once per chemotherapy cycle. Do not administer in period between 14 days before and 24 hr after administration of cytotoxic chemotherapy. Do not administer the 6 mg fixed-dose formulation in infants, children, and smaller adolescents weighing less than 45 kg.

General Advice

  • For subcutaneous administration only. Not for intradermal, IM, IV, intraarterial administration.
  • Avoid shaking syringe.
  • Do not administer if particulate matter, cloudiness, or discoloration noted.


Store prefilled syringes in original carton in refrigerator (36° to 46°F). Do not freeze. If accidentally frozen, allow to thaw in refrigerator before using. Discard syringe if frozen a second time. May allow syringe to reach room temperature before administering. If removed from refrigerator, keep syringe in original carton to protect from light and use within 48 hr. Discard syringe if left at room temperature for greater than 48 hr.

Drug Interactions

Drugs potentiating the release of neutrophils (eg, lithium)

Use drugs that potentiate the release of neutrophils with caution.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Fatigue; headache; insomnia; dizziness.




Nausea; diarrhea; vomiting; constipation; anorexia; taste perversion; dyspepsia; abdominal pain; stomatitis.


Granulocytopenia; leukocytosis.


Skeletal pain; myalgia; arthralgia; medullary bone pain.


Fever; generalized weakness; peripheral edema; mucositis; neutropenic fever.



Category C .




Safety and efficacy not established. Do not administer 6 mg fixed-dose formulation in infants, children, and smaller adolescents weighing less than 45 kg.


Allergic-type reactions, including anaphylaxis, skin rash, and urticaria may occur.

Adult respiratory distress syndrome

Adult respiratory distress syndrome may occur. Monitor patient for signs and symptoms of adult respiratory distress syndrome (eg, fever, respiratory distress).

Sickle cell disease

Use with caution because severe sickle cell crisis may occur in patients with sickle cell disease.

Splenic rupture

Because splenic rupture may occur, do not use pegfilgrastim for peripheral blood progenitor cell mobilization. Monitor patient for signs and symptoms of splenic enlargement (eg, left upper abdominal pain, shoulder tip pain).

Patient Information

  • Explain name, dose, action and potential side effects of drug. If patient or caregiver will be administering at home, review “Information for Patients and Caregivers” insert with the patient or caregiver. Ensure that the patient or caregiver understands how to store, prepare, and administer the dose, and dispose of used equipment and supplies. The first injection should be performed under the supervision of a qualified health professional.
  • Caution patient or caregiver that medication is not to be administered during the time interval beginning 14 days before to 24 hr after administration of chemotherapy.
  • Advise patient or caregiver to immediately report any of the following to their health care provider: fever or other signs of infection; sore throat; left upper stomach pain; shoulder tip pain; difficulty breathing; rash or hives.
  • Advise patient or caregiver to report intolerable injection site reactions or unusual symptoms to their health care provider.
  • Instruct women to notify health care provider if becoming pregnant, planning on becoming pregnant, or breastfeeding.
  • Instruct patient not to take any prescription or OTC medications or dietary supplements unless advised by health care provider.
  • Remind patient or caregiver that office visits and laboratory tests will be required to monitor therapy and to be sure to keep appointments.

Recent Drug Updates at DrugIndexOnline:

Cosopt Cosopt
Generic Name: dorzolamide and timolol ophthalmic (dor ZOLE a mide and TYE moe lole) Brand Names: Cosopt What is dorzolamide and timolol ophthalmic? Dorzolamide ophthalmic reduces the amount of fluid in the eye, which decreases pressure inside the eye. Timolol ophthalmic is a beta-blocker more...

Cytomegalovirus Immune Globulin Cytomegalovirus Immune Globulin
Generic Name: Cytomegalovirus Immune Globulin (sye-toe-MEG-a-loe-vye-rus) Brand Name: CytoGamCytomegalovirus Immune Globulin is used for:Reducing the risk of cytomegalovirus (CMV) disease associated with kidney, lung, liver, pancreas, and heart transplants. It may also be used for other condit more...

D-Tann CT Suspension D-Tann CT Suspension
Generic Name: Carbetapentane/Diphenhydramine/Phenylephrine Suspension (car-beta-PEN-tane/dye-fen-HYE-dra-meen/fen-ill-EF-rin) Brand Name: D-Tann CT and Dytan-CSD-Tann CT Suspension is used for:Relieving symptoms of sinus congestion, runny nose, sneezing, and cough due to colds, upper respirator more...

Erythromycin/Benzoyl Peroxide Erythromycin/Benzoyl Peroxide
Pronouncation: (eh-RITH-row-MY-sin/BEN-zoe-il) Class: Benzoyl peroxide combination Trade Names: Benzamycin - Gel 5% benzoyl peroxide, 3% erythromycin Mechanism of Action Pharmacology Exact mechanism not known, however, in part, due to antibacterial effect of erythromycin. The keratolytic and desqua more...

Gadoversetamide Diagnostic Gadoversetamide Diagnostic
This information applies to the following medicines: 1. Gadodiamide (gad-oh-DYE-a-mide) 2. Gadopentetate (gad-o-PEN-te-tate)† 3. Gadoteridol (gad-oh-TER-i-dol)† 4. Gadoversetamide (gad-oh-ver-SET-a-mide)† † Not commercially available in Canada Category more...

Note: Palladone (hydromorphone hydrochloride extended release capsules) was suspended from the U.S. market in July 2005 by the manufacturer. Serious side effects were reported when Palladone was taken with alcohol. Some commonly used brand names are: In the U.S.— Astramorph PF 10 more...

Naphuride Naphuride
Some commonly used brand names are: Antrypol Bayer 205 Belganyl 309 F Fourneau 309 Germanin Moranyl Naganin Naganol Naphuride *† Not commercially available in the U.S. and Canada. Category Antiprotozoal; Anthelmintic, systemic Description Suramin (SOO-ra-min) is used in the trea more...

Nystop Powder Nystop Powder
Generic Name: Nystatin Topical Powder (nye-STAT-in) Brand Name: NystopNystop Powder is used for:Treating certain fungal infections. It may also be used for other conditions as determined by your doctor. Nystop Powder is an antifungal. It works by killing sensitive fungi. Do NOT use Nystop Powder more...