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All about: Phenoxybenzamine

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Generic Name: Phenoxybenzamine (fen-ox-ee-BEN-za-meen)
Brand Name: Dibenzyline

Phenoxybenzamine is used for:

Treating high blood pressure and sweating caused by a certain kind of tumor (pheochromocytoma). It may also be used for other conditions as determined by your doctor.

Phenoxybenzamine is an alpha-blocker. It works by relaxing blood vessels, causing blood pressure to decrease.

Do NOT use Phenoxybenzamine if:

  • you are allergic to any ingredient in Phenoxybenzamine
  • you have a condition in which a fall in blood pressure may be undesirable

Contact your doctor or health care provider right away if any of these apply to you.

Before using Phenoxybenzamine :

Some medical conditions may interact with Phenoxybenzamine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have problems with the blood vessels of the heart or brain, heart problems, an irregular heartbeat, a lung or respiratory tract infection, or kidney problems

Some MEDICINES MAY INTERACT with Phenoxybenzamine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Epinephrine because severe low blood pressure may occur
  • Levarterenol or reserpine because effectiveness may be decreased by Phenoxybenzamine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenoxybenzamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Phenoxybenzamine :

Use Phenoxybenzamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • If you miss a dose of Phenoxybenzamine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Phenoxybenzamine .

Important safety information:

  • Phenoxybenzamine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Phenoxybenzamine . Using Phenoxybenzamine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Phenoxybenzamine may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Phenoxybenzamine .
  • Use Phenoxybenzamine with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is unknown if Phenoxybenzamine can cause harm to the fetus. If you become pregnant while taking Phenoxybenzamine , discuss with your doctor the benefits and risks of using Phenoxybenzamine during pregnancy. It is unknown if Phenoxybenzamine is excreted in breast milk. Do not breast-feed while taking Phenoxybenzamine .

Possible side effects of Phenoxybenzamine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; nasal congestion; stomach upset; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in sexual function; fainting; fast heartbeat; pinpoint pupils; severe dizziness or lightheadedness upon sitting or standing; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm ), or emergency room immediately. Symptoms may include fainting; fast heartbeat; severe dizziness, lightheadedness, or fainting, especially upon sitting or standing; severe tiredness or weakness; vomiting.

Proper storage of Phenoxybenzamine :

Store Phenoxybenzamine at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Phenoxybenzamine out of the reach of children and away from pets.

General information:

  • If you have any questions about Phenoxybenzamine , please talk with your doctor, pharmacist, or other health care provider.
  • Phenoxybenzamine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Phenoxybenzamine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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