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All about: piperacillin and tazobactam

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Generic Name: piperacillin and tazobactam (pi PER a sil in and tay zoe BAK tam )
Brand Names: Zosyn

What is piperacillin and tazobactam?

Piperacillin is an antibiotic in a group of drugs called penicillins. Piperacillin fights bacteria in the body.

Tazobactam is in a similar group of antibiotic drugs and also fights bacteria in the body.

The combination of piperacillin and tazobactam is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia.

Piperacillin and tazobactam may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about piperacillin and tazobactam?

Do not use this medication if you are allergic to piperacillin and tazobactam or to any other penicillin antibiotic, such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), carbenicillin (Geocillin), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), tircarillin (Ticar, Timentin), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.

Before using piperacillin and tazobactam tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, a history of any type of allergy, or if you are on a salt-restricted diet.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.

What should I discuss with my healthcare provider before using piperacillin and tazobactam?

Do not use this medication if you are allergic to piperacillin and tazobactam or to any other penicillin antibiotic, such as:
  • amoxicillin (Amoxil, Augmentin);

  • ampicillin (Omnipen, Principen);

  • carbenicillin (Geocillin);

  • dicloxacillin (Dycill, Dynapen);

  • oxacillin (Bactocill);

  • ticarcillin (Ticar, Timentin); or

  • penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).

Before using piperacillin and tazobactam, tell your doctor if you are allergic to any drugs (especially cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others), or if you have:

  • kidney disease (or if you are on dialysis);

  • a bleeding or blood clotting disorder;

  • an electrolyte imbalance such as low levels of potassium in your blood;

  • cystic fibrosis;

  • a history of any type of allergy; or

  • if you are on a salt-restricted diet.

If you have any of these conditions, you may not be able to use piperacillin and tazobactam, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Piperacillin and tazobactam may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use piperacillin and tazobactam?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Piperacillin and tazobactam is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be given instructions on how to inject your medicine at home. Do not use this medicine at home if you do not fully understand how to give the injection and properly dispose of needles and other items used in giving the medicine.

Piperacillin and tazobactam must be mixed with a liquid (diluent) before injecting it. Shake the medication and diluent until well dissolved. Do not mix the medicine or draw your dose into a syringe or IV bag until you are ready to give yourself an injection. Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription.

Piperacillin and tazobactam is usually given for 7 to 10 days, depending on the infection being treated. Follow your doctor's instructions.

Use each needle only one time. Throw away used needles and syringes in a puncture-proof container. If your medicine does not come with such a container, ask your pharmacist where you can get one. Keep this container out of the reach of children and pets. Your pharmacist can tell you how to properly dispose of the container.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Piperacillin and tazobactam will not treat a viral infection such as the common cold or flu.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using piperacillin and tazobactam.

Store unmixed piperacillin and tazobactam, and the liquid diluent, at cool room temperature. After mixing the medicine and diluent, you may store it at room temperature for up to 12 hours. Throw away any unused mixture that has not been used within that time. Mixed medication can also be stored in the refrigerator for up to 48 hours. Throw away any unused mixture that has not been used within that time.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a piperacillin and tazobactam overdose may include severe anxiety, agitation, feeling restless or nervous, or seizure (convulsions).

What should I avoid while using piperacillin and tazobactam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Piperacillin and tazobactam side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • diarrhea that is watery or bloody;

  • easy bruising or bleeding, unusual weakness;

  • dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;

  • fever, chills, body aches, flu symptoms; or

  • seizure (convulsions).

Less serious side effects may be more likely to occur, such as:

  • nausea, vomiting, stomach pain or upset;

  • constipation;

  • headache;

  • anxiety, sleep problems (insomnia);

  • skin rash or itching;

  • pain, swelling, or other irritation where the injection was given; or

  • vaginal yeast infection (itching or discharge).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect piperacillin and tazobactam?

Before using piperacillin and tazobactam, tell your doctor if you are using any of the following drugs:

  • probenecid (Benemid);

  • an antibiotic such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Mycifradin, Neo-Fradin, Neo-Tab), netilmicin (Netromycin), streptomycin, tobramycin (Nebcin, Tobi);

  • a blood thinner such as warfarin (Coumadin); or

  • any other medication used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), or urokinase (Abbokinase).

If you are using any of these drugs, you may not be able to use piperacillin and tazobactam, or you may need dosage adjustments or special tests during treatment.

There may be other drugs that can affect piperacillin and tazobactam. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist has information about piperacillin and tazobactam written for health professionals that you may read.

What does my medication look like?

Piperacillin and tazobactam is available with a prescription under the brand name Zosyn Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 06/06/2007 1:32:14 PM.

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