19 . June , 2019 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Primaquine Phosphate

Big Image Pronouncation: (PRIM-uh-kween FOSS-fate)
Class: Antimalarial

Trade Names:
Primaquine Phosphate
- Tablets 26.3 mg (equiv. to 15 mg base)

Mechanism of Action

Pharmacology

Disrupts metabolic processes of parasitic organism, eliminating tissue (exoerythrocytic) infection and preventing development of blood (erythrocytic) forms of parasite responsible for relapses of vivax malaria.

Pharmacokinetics

Absorption

Rapid. Bioavailability is approximately 96%. T max is approximately 2 to 3 hr (primaquine), approximately 7 hr (metabolite carboxyprimaquine). C max is 50 to 66 ng/mL (15 mg); 104 ng/mL (30 mg).

Distribution

Extensively distributed. Vd is 248 L. C max is 291 to 736 ng/mL (metabolite) and 432 to 1240 ng/mL (metabolite).

Metabolism

Rapidly converted to carboxyprimaquine. Undetermined if the main plasma metabolite has activity.

Elimination

Urine (less than 2% of dose). The t ½ is 5.8 hr (primaquine); 22 to 30 hr (metabolite carboxyprimaquine).

Indications and Usage

Radical cure or prevention of relapse in vivax malaria; after termination of chloroquine phosphate suppressive therapy in areas where vivax malaria is endemic.

Unlabeled Uses

With clindamycin, treatment of Pneumocystis carinii pneumonia associated with AIDS.

Contraindications

Concomitant administration of quinacrine and primaquine; acutely ill patient with systemic disease manifested by granulocytopenia (eg, rheumatoid arthritis, lupus erythematosus); concurrent administration of other potentially hemolytic or bone marrow depressant medications.

Dosage and Administration

Begin therapy during last 2 wk of or after course of suppression with chloroquine or comparable drug.

Adults

PO 26.3 mg (15 mg base) for 14 days.

Children

PO 0.5 mg/kg/day (0.3 mg/kg/day of base) for 14 days (max, 15 mg/day of base).

General Advice

Administer without regard to meals. Administer with food if GI upset occurs.

Storage/Stability

Store at room temperature in tightly closed, light-resistant container.

Drug Interactions

Quinacrine

May potentiate toxicity of antimalarial compounds that are structurally related to primaquine.

Laboratory Test Interactions

None well documented.

Adverse Reactions

GI

Nausea; vomiting; epigastric distress; abdominal cramps.

Hematologic

Leukopenia; hemolytic anemia in G-6-PD deficiency; methemoglobinemia in NADH methemoglobin reductase deficiency.

Precautions

Pregnancy

Pregnancy category undetermined.

Lactation

Undetermined. To avoid adverse effects in the infant, do not give to lactating women.

Hemolytic anemia

May occur in patients with following conditions: G-6-PD deficiency, NADH methemoglobin reductase deficiency; idiosyncratic reactions (leukopenia, methemoglobinemia; hemolytic anemia). Discontinue drug if marked darkening of urine or sudden decrease in hemoglobin or leukocyte count occurs.

Max dose

Hemolytic reactions may occur with doses of drug exceeding recommended dose.

Overdosage

Symptoms

Anemia, methemoglobinemia, leukopenia, acute abdominal cramps, vomiting, epigastric distress, CNS and cardiovascular disturbances, granulocytopenia, hemolytic anemia.

Patient Information

  • Tell patient that medicine may be taken with food if stomach upset (eg, nausea, vomiting, abdominal cramps) occurs, and advise patient to contact health care provider if upset persists.
  • Emphasize importance of compliance with drug regimen.
  • Advise patient to report marked darkening of urine to health care provider.

Recent Drug Updates at DrugIndexOnline:





Cortane Cortane
Generic Name: hydrocortisone topical (hye droe KOR ti sone) Brand Names: Acticort 100, Aeroseb-HC, Ala-Cort, Aloe Cort, Aquanil HC, Beta HC, Caldecort, Cetacort, Cort-Dome, Cortaid, Cortane, Corticaine, Corticreme, Cortizone-10, Cortizone-5, Cotacort, Delcort, Dermacort, Dermarest Plus An more...

Desoxyn Gradumet Desoxyn Gradumet
Generic Name: methamphetamine (meth am FET a meen) Brand Names: Desoxyn, Desoxyn Gradumet What is Desoxyn Gradumet (methamphetamine)? Methamphetamine is a central nervous system stimulant. It affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control more...

Dolsed Dolsed
Some commonly used brand names are: In the U.S.— Atrosept Dolsed Hexalol Prosed/DS Trac Tabs 2X UAA Uridon Modified Urimed Urinary Antiseptic No. 2 Urised Uriseptic Uritab Uritin Uro-Ves † Not commercially available in Canada. Category Anticholinergic-antibacterial-analgesic, more...

Filgrastim Filgrastim
Some commonly used brand names are: In the U.S.— Neupogen 1 Leukine 2 In Canada— Neupogen 1 Other commonly used names are: Granulocyte colony stimulating factor (G-CSF) Granulocyte-macrophage colony stimulating factor (GM-CSF) Note: For quick reference, the following colon more...

GlycoLax Powder for Oral Solution GlycoLax Powder for Oral Solution
Generic Name: Polyethylene Glycol-3350 Powder for Oral Solution (pol-ee-ETH-il-een GLIE-col) Brand Name: Examples include GlycoLax and MiraLaxGlycoLax Powder for Oral Solution is used for:Treating occasional constipation. GlycoLax Powder for Oral Solution is a laxative. It works by softening th more...

Lidocaine/Hydrocortisone Cream Lidocaine/Hydrocortisone Cream
Generic Name: Lidocaine/Hydrocortisone Cream (L YE-doe-kane /hye-droe-KOR-ti-sone) Brand Name: LidaMantle HCLidocaine/Hydrocortisone Cream is used for:Treating pain, itching, soreness, and discomfort of the skin or mucous membranes due to certain conditions such as eczema, scratches, minor burns more...

Methylin Chewable Tablets Methylin Chewable Tablets
Generic Name: Methylphenidate Chewable Tablets (meth-il-FEN-i-date) Brand Name: MethylinUse Methylin Chewable Tablets with caution if you have a history of emotional problems, or alcohol or substance abuse. Abuse of Methylin Chewable Tablets may cause it to not work as well. Abuse may also lead more...

PanOxyl Aquagel 2.5 Topical PanOxyl Aquagel 2.5 Topical
Some commonly used brand names are: In the U.S.— Acne-Aid Vanishing Cream Acne-Aid Aqua Gel Ambi 10 Acne Medication Benoxyl 5 Lotion Benoxyl 10 Lotion Benzac AC 21/2 Gel Benzac AC 5 Gel Benzac AC 10 Gel Benzac AC Wash 21/2 Benzac AC Wash 5 Benzac AC Wash 10 Benzac 5 Gel Benzac 10 Gel Benz more...