19 . July , 2018 - Thursday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Propafenone

Big Image

Some commonly used brand names are:

In the U.S.—

  • Rythmol
  • Rythmol SR

In Canada—

  • Rythmol

Category

  • Antiarrhythmic

Description

Propafenone (proe-pa-FEEN-none) belongs to the group of medicines known as antiarrhythmics. It is used to treat abnormal heart rhythms.

Propafenone produces its helpful effects by slowing nerve impulses in the heart and making the heart tissue less sensitive.

There is a chance that propafenone may cause new heart rhythm problems or make worse those that already exist. Since similar medicines have been shown to cause severe problems in some patients, propafenone is only used to treat serious heart rhythm problems. Discuss this possible effect with your doctor.

This medicine is available only with your doctor's prescription, in the following dosage form:

  • Oral
  • Extended-release tablets (U.S.)
  • Tablets (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For propafenone, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to propafenone. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Propafenone has not been studied in pregnant women. Although this medicine has not been shown to cause birth defects in animal studies, it has been shown to reduce fertility in monkeys, dogs, and rabbits. In addition, in rats it caused decreased growth in the infant and deaths of mothers and infants. Before taking propafenone, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—Propafenone passes into breast milk. Because of the potential for problems in the nursing infant, propafenone is generally not recommended in mothers who are breast-feeding.

Children—Propafenone can cause serious side effects in any patient. Therefore, it is especially important that you discuss with the child's doctor the good that this medicine may do as well as the risks of using it.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of propafenone in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking propafenone it is especially important that your health care professional know if you are taking either of the following:

  • Amiodarone (e.g., Cordarone) or
  • Class Ia and III antiarrhythmic agents (disopyramide [e.g., Norpace], dofetilide [e.g., Tikosyn], procainamide [e.g., Procanbid], quinidine [e.g., Cardioquin]) or
  • Drugs that prolong QT interval (amitriptyline [e.g., Elavil], bepridil [e.g., Vascor], chlorpromazine [e.g., Thorazine], cisapride [e.g., Propulsid], clarithromycin, erythromycin)—Using any of these medicines together with propafenone is not recommended
  • Digoxin (e.g., Lanoxin) or
  • Warfarin (e.g., Coumadin)—Effects of these medicines may be increased when used with propafenone

Other medical problems—The presence of other medical problems may affect the use of propafenone. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma or
  • Bronchitis or
  • Emphysema—Propafenone can increase trouble in breathing
  • Bradycardia (unusually slow heartbeat)—There is a risk of further decreased heart function
  • Congestive heart failure or other heart disease or
  • Myasthenia gravis or
  • Severe low blood pressure—Propafenone may make these conditions worse
  • Electrolyte (i.e., potassium) disorders—Propafenone may worsen heart rhythm problems
  • Kidney disease or
  • Liver disease—Effects of propafenone may be increased because of slower removal from the body
  • If you have a pacemaker—Propafenone may interfere with the pacemaker and require more careful follow-up by the doctor

Proper Use of This Medicine

Take propafenone exactly as directed by your doctor . Do not take more or less of this medicine, and do not take it more often than your doctor ordered.

For patients taking the extended-release capsule form of this medicine

  • Swallow capsules whole. Do not crush, break, or chew them.
  • This medicine may be taken with or without food

Grapefruit and grapefruit juice may increase the effects of propafenone by increasing the amount of this medicine in the body. You should not eat grapefruit or drink grapefruit juice while you are taking this medicine .

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night . For example, if you are to take 3 doses a day, doses should be spaced about 8 hours apart. If you need help in planning the best times to take your medicine, check with your health care professional.

Dosing—The dose of propafenone will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of propafenone. If your dose is different, do not change it unless your doctor tells you to do so:

  • The number of extended-release capsule or tablets that you take depends on the strength of the medicine.
  • For oral extended-release dosage form (capsules):
    • Adults—At first, 225 milligrams (mg) once every twelve hours. Your doctor may increase your dose as needed. However, the dose usually is not more than 450 mg every 12 hours
    • Children: Use and dose must be determined by your doctor
  • For oral dosage forms (tablets):
    • Adults: 150 milligrams every eight hours. Your doctor may increase your dose if needed.
    • Children: Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of propafenone and remember within 4 hours, take it as soon as possible. However, if you do not remember until later, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

It is important that your doctor check your progress at regular visits to make sure the medicine is working properly. This will allow changes to be made in the amount of medicine you are taking, if necessary.

Tell your doctor about all medications you are taking, prescription and over-the-counter (OTC)

Your doctor may want you to carry a medical identification card or bracelet stating that you are using this medicine.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine .

Propafenone may cause some people to become dizzy or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Chest pain; shortness of breath; fast, irregular, or slow heartbeat, dizziness, and/or fainting; swelling of feet or lower legs; weight gain

Rare

Chills, fever, and weakness; joint pain; trembling or shaking

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Change in taste or bitter or metallic taste

Less common

Blurred vision; constipation or diarrhea; dryness of mouth; headache; nausea and/or vomiting; skin rash; unusual tiredness or weakness

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 12/22/2004

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

Recent Drug Updates at DrugIndexOnline:





Amifostine Amifostine
Generic Name: Amifostine (am-i-FOS-teen) Brand Name: EthyolAmifostine is used for:Reducing kidney damage due to cisplatin chemotherapy in patients with ovarian cancer. It is also used to reduce moderate to severe dry mouth associated with radiation treatment after surgery for head and neck canc more...

Atasol-30 Atasol-30
Some commonly used brand names are: In the U.S.— Allay 4 Anexsia 5/500 4 Anexsia 7.5/650 4 Anolor DH 5 4 Bancap-HC 4 Capital with Codeine 1 Co-Gesic 4 Darvocet-N 50 7 Darvocet-N 100 7 DHCplus 3 Dolacet 4 Dolagesic 4 Duocet 4 E-Lor 7 Endocet 5 EZ III 1 Hycomed 4 Hyco-Pap 4 Hydrocet 4 Hydro more...

Fluphenazine Concentrate Fluphenazine Concentrate
Generic Name: Fluphenazine Oral Concentrate (floo-FEN-a-zeen) Brand Name: Generic only. No brands available.Fluphenazine Concentrate is used for:Treating certain mental or mood disorders (eg, schizophrenia). It may also be used for other conditions as determined by your doctor. Fluphenazine Conce more...

Maximum Strength Phazyme Maximum Strength Phazyme
Some commonly used brand names are: In the U.S.— Extra Strength Maalox Anti-Gas Flatulex Gas Relief Gas-X Gas-X Extra Strength Genasyme Maalox Anti-Gas Maximum Strength Gas Relief Maximum Strength Mylanta Gas Relief Maximum Strength Phazyme My Baby Gas Relief Drops Mylanta Gas Mylanta Gas more...

Mexitil Mexitil
Generic Name: mexiletine (mex ILL eh teen) Brand Names: Mexitil What is Mexitil (mexiletine)? Mexiletine affects the way that your heart beats. Mexiletine is used to treat seriously irregular heartbeats. Mexiletine may also be used for purposes other than those listed in this medication more...

Myrac Myrac
Generic Name: Minocycline Tablets (mi-noe-SYE-kleen) Brand Name: Dynacin and MyracMyrac is used for:Treating infections caused by certain bacteria. It is also used with other medicines to treat severe acne. It may also be used for other conditions as determined by your doctor. Myrac is a tetr more...

Ophthaine Ophthalmic Ophthaine Ophthalmic
Some commonly used brand names are: In the U.S.— Ak-Taine 1 Ak-T-Caine 2 Alcaine 1 Ocu-Caine 1 Ophthaine 1 Ophthetic 1 Opticaine 2 Pontocaine 2 Spectro-Caine 1 In Canada— Alcaine 1 Diocaine 1 Minims Tetracaine 2 Ophthetic 1 Pontocaine 2 Other commonly used names are: Amethocaine more...

Prednisolone Sodium Phosphate Drops Prednisolone Sodium Phosphate Drops
Generic Name: Prednisolone Sodium Phosphate Eye Drops (pred-NISS-oh-lone SO-dee-uhm FOSS-fate) Brand Name: AK-Pred and Inflamase FortePrednisolone Sodium Phosphate Drops is used for:Treating inflammation of the eyes and eyelids due to certain conditions. It may also be used for other conditions more...