23 . February , 2019 - Saturday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Bacitracin Zinc/Neomycin Sulfate/Polymyxin B Sulfate/Hydrocortisone

Big Image Pronouncation: (Bass-ih-TRAY-sin zingk/NEE-oh-MY-sin SULL-fate/pal-ee-MIX-in BEE SULL-fate/HIGH-droe-CORE-tih-sone)
Class: Antibiotic, Corticosteroid

Trade Names:
Cortisporin
- Ointment 400 units/g bacitracin zinc, 3.5 mg/g neomycin, 5,000 units/g polymyxin B, 1% hydrocortisone

Mechanism of Action

Pharmacology

Neomycin

Inhibits protein synthesis by binding to ribosomal RNA, causing bacterial genetic code misreading.

Polymyxin B

Interacts with phospholipid components of bacterial cell membrane, increasing cell wall permeability.

Bacitracin

Interferes with bacterial cell wall synthesis by inhibiting regeneration of phospholipid receptors involved with paptidoglycan synthesis.

Hydrocortisone

Suppresses inflammatory response.

Indications and Usage

Treatment of corticosteroid-responsive dermatoses with secondary infection.

Contraindications

Use in the eyes or external ear canal (if the eardrum is perforated); tuberculosis; fungal or viral (eg, varicella zoster) lesions of the skin; hypersensitivity to any of components of product.

Dosage and Administration

Topical Apply thin film to affected area 2 to 4 times daily, not to exceed 7 days.

Storage/Stability

Store at controlled room temperature (59° to 86°F). Keep tube tightly closed.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Acneiform eruption, allergic contact dermatitis, burning, dryness, folliculitis, hypertrichosis, hypopigmentation, itching, maceration of the skin, miliaria, perioral dermatitis, secondary infection, skin atrophy, skin sensitization, striae.

EENT

Ototoxicity.

Genitourinary

Nephrotoxicity.

Miscellaneous

Allergic sensitivity.

Precautions

Pregnancy

Category C .

Lactation

Hydrocortisone is excreted in breast milk following oral administration.

Children

Safety and efficacy in children not established.

Superinfection

Prolonged use may result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

Adrenal suppression

Signs and symptoms of exogenous hyperadrenocorticism can occur with use of topical corticosteroids, especially if occlusive dressings are used.

Bacterial resistance

Bacterial resistance to components of the product may develop.

Patient Information

  • Review prescribed dosing schedule with patient or caregiver.
  • Remind patient or caregiver that ointment is not to be used in the eye or ear (if the eardrum is perforated).
  • Teach patient or caregiver proper technique for applying ointment: Wash hands; apply thin film to affected area(s) using fingers or applicator. Wash hands after applying ointment.
  • Advise patient or caregiver to contact health care provider if local redness or swelling develops or if skin lesions do not improve or worsen.

Recent Drug Updates at DrugIndexOnline:





Acetaminophen/Pseudoephedrine/Triprolidine Acetaminophen/Pseudoephedrine/Triprolidine
Generic Name: Acetaminophen/Pseudoephedrine/Triprolidine Tablets (a-seet-a-MIN-oh-fen/soo-doe-e-FED-rin/try-PRO-li-deen) Brand Name: Actifed PlusAcetaminophen/Pseudoephedrine/Triprolidine is used for:Temporarily relieving symptoms of hay fever, allergies, or the common cold, including pain, fev more...

AK-Dex Ophthalmic AK-Dex Ophthalmic
Some commonly used brand names are: In the U.S.— AK-Dex 2 AK-Pred 6 AK-Tate 6 Baldex 2 Decadron 2 Dexair 2 Dexotic 2 Econopred 6 Econopred Plus 6 Eflone 3 Flarex 3 Fluor-Op 3 FML Forte 3 FML Liquifilm 3 FML S.O.P. 3 HMS Liquifilm 5 Inflamase Forte 6 Inflamase Mild 6 I-Pred 6 Lite Pred 6 M more...

Arnica Tincture Arnica Tincture
Generic Name: Arnica Tincture (ARE-nih-ka) Brand Name: Generic only. No brands available.Arnica Tincture is used for:Temporarily relieving irritation from minor bruising and soreness. It may also be used for other conditions as determined by your doctor. Arnica Tincture is a counterirritant. Exac more...

Aspirin and Codeine Aspirin and Codeine
Some commonly used brand names are: In the U.S.— Damason-P 5 Darvon Compound-65 9 Empirin with Codeine No.3 2 Empirin with Codeine No.4 2 Endodan 6 Lortab ASA 5 Panasal 5/500 5 PC-Cap 9 Percodan 6 Percodan-Demi 6 Propoxyphene Compound-65 9 Roxiprin 6 Synalgos-DC 1 Talwin Compound 7 In Ca more...

Chloral Hydrate Chloral Hydrate
Generic Name: Chloral Hydrate Capsules (KLOR-uhl HYE-drate) Brand Name: SomnoteChloral Hydrate is used for:Treating sleep disorders. It may be used to prevent symptoms of alcohol withdrawal or to treat existing withdrawal symptoms. It may also be used to produce sedation or sleep before certain more...

Kenalog-H Topical Kenalog-H Topical
Some commonly used brand names are: In the U.S.— Alphatrex 3 Aristocort 20 Aristocort A 20 Betatrex 3 Beta-Val 3 Bio-Syn 9 Cordran 11 Cordran SP 11 Cormax 4 Cutivate 12 Cyclocort 1 Delta-Tritex 20 Dermabet 3 Dermatop 19 Diprolene 3 Diprolene AF 3 Diprosone 3 Elocon 18 Florone 7 Florone E more...

Oxandrolone Oxandrolone
Pronouncation: (ox-AN-droe-lone) Class: Anabolic steroid Trade Names: Oxandrin - Tablets 2.5 mg - Tablets 10 mg Mechanism of Action Pharmacology Suppresses gonadotropic functions of the pituitary and may exert a direct effect upon the testes. Indications and Usage Adjunctive therapy to promote weig more...

Promethazine/Codeine Syrup Promethazine/Codeine Syrup
Generic Name: Promethazine/Codeine Syrup (proe-METH-a-zeen/KOE-deen) Brand Name: Generic only. No brands available.Promethazine/Codeine Syrup may cause severe and sometimes fatal breathing problems in children. Do NOT use Promethazine/Codeine Syrup in children younger than 16 years old. Do not gi more...