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All about: Carbinoxamine/Phenylephrine Sustained-Release Tablets

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Generic Name: Carbinoxamine/Phenylephrine Sustained-Release Tablets (kar-bi-NOX-a-meen/fen-ill-EFF-rin)
Brand Name: Norel LA

Carbinoxamine/Phenylephrine Sustained-Release Tablets is used for:

Relieving nasal symptoms (eg, congestion, runny nose, sneezing) and cough associated with allergies or the common cold.

Carbinoxamine/Phenylephrine Sustained-Release Tablets is an antihistamine and decongestant combination. It works by blocking the action of histamine and reducing the symptoms of an allergic reaction. It also relieves nasal congestion by causing vasoconstriction and shrinkage of the nasal mucous membranes and promoting drainage.

Do NOT use Carbinoxamine/Phenylephrine Sustained-Release Tablets if:

  • you are allergic to any ingredient in Carbinoxamine/Phenylephrine Sustained-Release Tablets
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or other severe heart problems
  • you are taking sodium oxybate (GHB) or droxidopa, or if you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Carbinoxamine/Phenylephrine Sustained-Release Tablets:

Some medical conditions may interact with Carbinoxamine/Phenylephrine Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of high blood pressure, diabetes, increased pressure in the eye (glaucoma), an enlarged prostate or other prostate problems, asthma, heart problems (eg, ischemic heart disease, irregular heartbeat), blood vessel problems, stomach or urinary blockage, adrenal gland problems, seizures, stroke, trouble urinating, trouble sleeping, or an overactive thyroid

Some MEDICINES MAY INTERACT with Carbinoxamine/Phenylephrine Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Carbinoxamine/Phenylephrine Sustained-Release Tablets's side effects
  • Benzodiazepines (eg, diazepam), bromocriptine, hydantoins (eg, phenytoin), or sodium oxybate (GHB) because the risk of their side effects may be increased by Carbinoxamine/Phenylephrine Sustained-Release Tablets
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Carbinoxamine/Phenylephrine Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Carbinoxamine/Phenylephrine Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Carbinoxamine/Phenylephrine Sustained-Release Tablets:

Use Carbinoxamine/Phenylephrine Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Carbinoxamine/Phenylephrine Sustained-Release Tablets may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow Carbinoxamine/Phenylephrine Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing. Some brands of Carbinoxamine/Phenylephrine Sustained-Release Tablets may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.
  • If you miss a dose of Carbinoxamine/Phenylephrine Sustained-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Carbinoxamine/Phenylephrine Sustained-Release Tablets.

Important safety information:

  • Carbinoxamine/Phenylephrine Sustained-Release Tablets may cause drowsiness, dizziness, or changes in vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Carbinoxamine/Phenylephrine Sustained-Release Tablets. Using Carbinoxamine/Phenylephrine Sustained-Release Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medicines that cause drowsiness (eg, sedatives, tranquilizers) while taking Carbinoxamine/Phenylephrine Sustained-Release Tablets. Carbinoxamine/Phenylephrine Sustained-Release Tablets will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Do not exceed the recommended dose or use Carbinoxamine/Phenylephrine Sustained-Release Tablets for longer than prescribed without checking with your doctor.
  • Do not use Carbinoxamine/Phenylephrine Sustained-Release Tablets for persistent or chronic cough, such as a cough that occurs with smoking, asthma, or emphysema, or if the cough is accompanied by excessive mucus, unless directed by your doctor.
  • If you are scheduled for allergy skin testing, do not take Carbinoxamine/Phenylephrine Sustained-Release Tablets for several days before the test because it may decrease your response to the skin tests.
  • If you have trouble sleeping, ask your pharmacist or doctor about the best time of day to take Carbinoxamine/Phenylephrine Sustained-Release Tablets.
  • Do not take diet or appetite control medicines while you are taking Carbinoxamine/Phenylephrine Sustained-Release Tablets without checking with your doctor.
  • Carbinoxamine/Phenylephrine Sustained-Release Tablets contains phenylephrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains phenylephrine. If it does or if you are uncertain, contact your doctor or pharmacist.
  • Use Carbinoxamine/Phenylephrine Sustained-Release Tablets with caution in the ELDERLY because they may be more sensitive to its effects, especially sleeplessness.
  • Use Carbinoxamine/Phenylephrine Sustained-Release Tablets with caution in CHILDREN because they may be more sensitive to its effects, especially drowsiness and excitability.
  • Use Carbinoxamine/Phenylephrine Sustained-Release Tablets with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Carbinoxamine/Phenylephrine Sustained-Release Tablets, discuss with your doctor the benefits and risks of using Carbinoxamine/Phenylephrine Sustained-Release Tablets during pregnancy. Carbinoxamine/Phenylephrine Sustained-Release Tablets may cause harm to the fetus if taken during late pregnancy. It is unknown if Carbinoxamine/Phenylephrine Sustained-Release Tablets is excreted in breast milk. Do not breast-feed while using Carbinoxamine/Phenylephrine Sustained-Release Tablets.

Possible side effects of Carbinoxamine/Phenylephrine Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; diarrhea; dizziness; drowsiness; dry mouth, throat, or nose; excitability; headache; heartburn; nausea; nervousness; restlessness; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty urinating; double vision; fast or irregular heartbeat; fever; frequent or painful urination; hallucinations; paleness; seizures; severe nervousness, anxiety, or excitability; severe or persistent headache or dizziness; tremor.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; decreased mental alertness; enlarged pupils; fast, slow, or irregular heartbeat; flushing or pale skin; hallucinations; increased thirst or urination; loss of coordination; one-sided weakness; seizures; severe or persistent drowsiness, dizziness, or vomiting; speech or vision problems; tremors; trouble breathing.

Proper storage of Carbinoxamine/Phenylephrine Sustained-Release Tablets:

Store Carbinoxamine/Phenylephrine Sustained-Release Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Carbinoxamine/Phenylephrine Sustained-Release Tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Carbinoxamine/Phenylephrine Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Carbinoxamine/Phenylephrine Sustained-Release Tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Carbinoxamine/Phenylephrine Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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