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All about: dapsone

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Generic Name: dapsone (DAP sone)
Brand Names:

What is dapsone?

Dapsone is an antiinfective medication.

Dapsone is used in the treatment of dermatitis herpetiformis (a skin condition) and leprosy (Hansen's disease).

Dapsone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about dapsone?

In rare cases, dapsone has been associated with serious, and sometimes fatal blood and liver problems. Contact your doctor immediately if you experience a sore throat, fever, pale skin, bruising or pinpoint red spots on the skin, or yellowing of the skin or eyes. These may be symptoms of blood or liver problems. Contact your doctor immediately if you develop a rash while taking dapsone. In rare cases, dapsone has been associated with serious, and sometimes fatal, skin reactions.

What should I discuss with my healthcare provider before taking dapsone?

Do not take dapsone without first talking to your doctor if you have
  • glucose 6-phosphate dehydrogenase (G6PD) deficiency;

  • methemoglobin reductase deficiency (hemoglobin M); or

  • liver disease.

You may not be able to take dapsone, or you may require a dosage adjustment or special monitoring if you have any of the conditions listed above.

Dapsone is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Do not take dapsone without first talking to your doctor if you are pregnant or could become pregnant during treatment. Dapsone passes into breast milk and may affect a nursing baby. Do not take dapsone without first talking to your doctor if you are nursing a baby.

How should I take dapsone?

Take dapsone exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Taking dapsone with food may decrease stomach upset, should it occur.

It is important to take dapsone regularly to get the most benefit.

Your doctor may want you to have blood tests or other forms of monitoring during treatment with dapsone.

Store dapsone at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication, unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a dapsone overdose may include nausea, vomiting, excitation, seizures, and bluish skin color.

What should I avoid while taking dapsone?

Avoid prolonged exposure to sunlight. Dapsone may increase the sensitivity of the skin to sunlight and sunburn may be more likely to occur. If exposure to the sun is unavoidable, wear a sunscreen and protective clothing.

Dapsone side effects

In rare cases, dapsone has been associated with serious, and sometimes fatal blood and/or liver problems. Contact your doctor immediately if you experience a sore throat, fever, pale skin, bruising or pinpoint red spots on the skin, or yellowing of the skin or eyes. These may be symptoms of blood or liver problems. Contact your doctor immediately if you develop a rash while taking dapsone. In rare cases, dapsone has been associated with serious, and sometimes fatal, skin reactions. If you experience any of the following serious side effects, seek emergency medical attention or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  • bluish skin color;

  • muscle weakness;

  • numbness or tingling;

  • abdominal pain;

  • difficulty breathing;

  • dark colored urine or pale colored stools; or

  • unusual tiredness.

Other, less serious side effects may be more likely to occur. Notify your doctor if you experience

  • nausea or vomiting;

  • blurred vision;

  • ringing in the ears;

  • headache;

  • insomnia; or

  • increased sensitivity of the skin to sunlight.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect dapsone?

Many other drugs can interact with dapsone, especially those that may also affect the blood. Do not take any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with dapsone without first talking to your doctor.

Where can I get more information?

  • Your pharmacist has more information about dapsone written for health professionals that you may read.

What does my medication look like?

Dapsone is available with a prescription as a generic drug product. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.03. Revision Date: 7/18/05 11:44:33 AM.

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