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All about: Demser

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Generic Name: Metyrosine (meh-TYE-row-seen)
Brand Name: Demser

Demser is used for:

Decreasing the amount of certain chemicals (catecholamines) in the body caused by a type of adrenal gland tumor (pheochromocytoma). It may be used either as a pretreatment before surgery or for the long-term treatment of symptoms associated with this disorder.

Demser is a catecholamine synthesis inhibitor. It works by reducing the amount of catecholamines in the body.

Do NOT use Demser if:

  • you are allergic to any ingredient in Demser

Contact your doctor or health care provider right away if any of these apply to you.

Before using Demser :

Some medical conditions may interact with Demser . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you drink alcohol or take medicines that can cause drowsiness

Some MEDICINES MAY INTERACT with Demser . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Haloperidol or phenothiazines (eg, chlorpromazine) because the risk of extrapyramidal effects (eg, involuntary muscle movements of the head, neck, or limbs; speech difficulty; tremors) may be increased when taking Demser
  • Medicines for sleep (eg, zolpidem), medicines for anxiety (eg, diazepam), or tranquilizers (eg, olanzapine) because severe drowsiness may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Demser may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Demser :

Use Demser as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Demser may be taken with or without food.
  • Drink plenty of fluids (at least 8 to 10 glasses per day) while taking Demser .
  • If you miss a dose of Demser , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Demser .

Important safety information:

  • Demser may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Demser . Using Demser alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Demser . Demser will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Before you have any medical or dental treatments or surgery, tell the doctor or dentist that you are taking Demser .
  • Demser is not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you are pregnant or plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is unknown if Demser is excreted in breast milk. If you are or will be breast-feeding while you are using Demser , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Demser :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Moderate to severe drowsiness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; confusion; crystals in the urine; depression; diarrhea; difficulty speaking; disorientation; drooling; hallucinations; painful urination; speech difficulty; swelling of the arms, legs, ankles, or feet; tremor.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include diarrhea; dry mouth; severe drowsiness; tightening of the jaw; tremor of the hands and body.

Proper storage of Demser :

Store Demser at room temperature between 68 and 77 degrees F (20 and 25 degrees C) away from heat, moisture, and light. Do not store in the bathroom. Keep Demser out of the reach of children and away from pets.

General information:

  • If you have any questions about Demser , please talk with your doctor, pharmacist, or other health care provider.
  • Demser is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Demser . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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