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All about: Desyrel

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Generic Name: Trazodone (TRAZ-oh-done)
Brand Name: Desyrel

Antidepressants may increase the risk of suicidal thoughts or actions in children and teenagers. The risk may be greater during the first few months that patients take Desyrel . Be sure that the benefits of using Desyrel outweigh the risks. Talk with the patients doctor if you have any questions.

Family and caregivers must closely observe patients who take Desyrel . It is important to keep in close contact with the patients doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior.


Desyrel is used for:

Treating depression. It may also be used for relief of an anxiety disorder (eg, sleeplessness, tension), chronic pain. It may also be used for other conditions as determined by your doctor.

Desyrel is a tetracyclic antidepressant. It is thought to increase the activity of one of the brain chemicals (serotonin), which helps elevate mood.

Do NOT use Desyrel if:

  • you are allergic to any ingredient in Desyrel or nefazodone
  • you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Desyrel :

Some medical conditions may interact with Desyrel . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart disease including irregular heartbeat or have had a heart attack
  • if you have a history of depression or suicidal tendencies
  • if you are scheduled to have surgery
  • if you consume alcoholic beverages

Some MEDICINES MAY INTERACT with Desyrel . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Carbamazepine, ethanol, ginkgo biloba, HIV protease inhibitors (eg, ritonavir), phenothiazines (eg, thioridazine), or serotonin reuptake inhibitors (eg, fluoxetine) because side effects, such as increased drowsiness or blurred vision, may occur
  • Buspirone, carbamazepine, digoxin, hydantoins (eg, phenytoin), itraconazole, ketoconazole, nefazodone, serotonin reuptake inhibitors (eg, fluoxetine), or sodium oxybate (GHB) because the risk of their side effects may be increased by Desyrel
  • Anticoagulants (eg, warfarin) because they may decrease Desyrel 's effectiveness. Your doctor may want to adjust your dose while taking Desyrel

This may not be a complete list of all interactions that may occur. Ask your health care provider if Desyrel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Desyrel :

Use Desyrel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Desyrel comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Desyrel refilled.
  • Take Desyrel shortly after a meal or light snack.
  • It may take 1 to 4 weeks for Desyrel to work. Do not stop taking Desyrel without checking with your doctor.
  • If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up. If more than one dose is missed, restart medication and advise your doctor or pharmacist at your next appointment.

Ask your health care provider any questions you may have about how to use Desyrel .

Important safety information:

  • Desyrel may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Desyrel with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Desyrel ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Children and teenagers who take Desyrel may be at increased risk for suicidal thoughts or actions. Adults may also be affected. The risk may be greater in patients who have had suicidal thoughts or actions in the past. The risk may also be greater in patients who have had bipolar (manic-depressive) illness, or if their family members have had it. Watch patients who take Desyrel closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Tell your doctor or dentist that you take Desyrel before you receive any medical or dental care, emergency care, or surgery.
  • Desyrel should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • Desyrel may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems, such as impotence. Contact your doctor right away if this happens.
  • PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Desyrel while you are pregnant. Desyrel is found in breast milk. If you are or will be breast-feeding while you use Desyrel , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Desyrel :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; decreased appetite; dizziness; drowsiness; dry mouth; general body discomfort; headache; incoordination; light-headedness; muscle aches/pains; nausea; nervousness; sleeplessness; stomach pain; stuffy nose; swelling of the skin; tiredness; tremors.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in urine; chest pain; fainting; hallucinations; irregular heartbeat; light-headedness when rising from a lying or seated position; prolonged, inappropriate, or painful erections; seizures; shortness of breath; stroke; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include loss of consciousness; low blood pressure; seizures; slow heart rate; slow, rapid or irregular pulse; slowed breathing; unusual drowsiness or dizziness; vomiting; weakness.

Proper storage of Desyrel :

Store Desyrel at room temperature, between 68 and 77 degrees F (20 and 25 degrees C) in a tight, light-resistant container. Store away from heat, moisture, and light. Protect from temperatures above 104 degrees F (40 degrees C). Do not store in the bathroom. Keep Desyrel out of the reach of children and away from pets.

General information:

  • If you have any questions about Desyrel , please talk with your doctor, pharmacist, or other health care provider.
  • Desyrel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Desyrel . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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