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All about: Dexedrine

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Generic Name: Dextroamphetamine Tablets (DEX-troe-am-FET-a-meen)
Brand Name: Dextrostat

Dexedrine has a high risk for abuse. It may be habit forming when used for a long period of time. Use Dexedrine only as prescribed. Do not share it with others.


Dexedrine is used for:

Treating attention deficit disorder with hyperactivity in children. It is also used to treat a type of sleep disorder (narcolepsy). It may also be used for other conditions as determined by your doctor.

Dexedrine is an amphetamine. Exactly how Dexedrine works is not known. It affects certain chemicals in the brain that may help improve attention span, behavior, and certain sleep disorders.

Do NOT use Dexedrine if:

  • you are allergic to any ingredient in Dexedrine or to similar medicines
  • you have severe hardening of the arteries; active heart or blood vessel disease; moderate, severe, or uncontrolled high blood pressure; high blood pressure in the lungs; anorexia; an overactive thyroid; or glaucoma
  • you have agitation, anxiety, or tension
  • you take guanethidine or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • you have a history of alcohol or other substance abuse

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dexedrine :

Some medical conditions may interact with Dexedrine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you or a family member have a history of mental or mood problems (eg, bipolar disorder, depression, psychosis), uncontrolled muscle movements (eg, tics), Tourette syndrome, or suicidal thoughts or attempts
  • if you have a history of seizures, growth problems, thyroid problems, heart problems (eg, heart failure, heart rhythm problems), birth defects, high blood pressure, certain blood problems (eg, porphyria), hardening of the arteries, or blood vessel problems, or you have had a recent heart attack
  • if you have a family history of sudden death or heart rhythm problems

Some MEDICINES MAY INTERACT with Dexedrine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Furazolidone, MAOIs (eg, phenelzine ), or propoxyphene because the risk of high blood pressure, dizziness, and decreased heart rate may be increased
  • Ammonium chloride, ascorbic acid (vitamin C), chlorpromazine, glutamic acid, haloperidol, lithium carbonate, methenamine, reserpine, or sodium acid phosphate because they may decrease Dexedrine 's effectiveness
  • Acetazolamide, sodium bicarbonate, or thiazide diuretics (eg, hydrochlorothiazide) because they may increase the risk of Dexedrine 's side effects
  • Meperidine, norepinephrine, phenobarbital, phenytoin, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), tramadol, or tricyclic antidepressants (eg, desipramine) because the risk of their side effects may be increased by Dexedrine
  • Antihistamines (eg, diphenhydramine), beta-blockers (eg, atenolol), certain blood pressure medicines, ethosuximide, or guanethidine because their effectiveness may be decreased by Dexedrine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dexedrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dexedrine :

Use Dexedrine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Dexedrine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Dexedrine refilled.
  • Take Dexedrine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Do not drink fruit juice at the same time that you take Dexedrine . Certain fruit juices (eg, grapefruit, apple, orange) may decrease Dexedrine 's effectiveness.
  • If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dexedrine .

Important safety information:

  • Dexedrine may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Dexedrine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • This product may contain tartrazine dye (FD&C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Dexedrine may cause sleeplessness. Do not take Dexedrine near your bedtime unless your doctor tells you otherwise.
  • Avoid large amounts of caffeine-containing foods and beverages, such as coffee, tea, cocoa, cola drinks, and chocolate. Caffeine may increase the side effects of Dexedrine .
  • Tell your doctor or dentist that you take Dexedrine before you receive any medical or dental care, emergency care, or surgery.
  • Dexedrine may interfere with certain lab tests, including corticosteroid levels. Be sure your doctor and lab personnel know you are taking Dexedrine .
  • Dexedrine should not be used in CHILDREN younger than 3 years old; safety and effectiveness in these children have not been confirmed.
  • Dexedrine may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they take Dexedrine .
  • PREGNANCY and BREAST-FEEDING: It is not known if Dexedrine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dexedrine while you are pregnant. Dexedrine is found in breast milk. Do not breast-feed while taking Dexedrine .

Some people who use Dexedrine for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you suddenly stop taking Dexedrine , you may experience WITHDRAWAL symptoms. These may include severe or unusual sadness, agitation, or fatigue.

Possible side effects of Dexedrine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; difficulty sleeping; dizziness; dry mouth; headache; loss of appetite; nausea; nervousness; restlessness; trouble sleeping; unpleasant taste; upset stomach; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; change in sexual ability or desire; chest pain; fainting; fast or irregular heartbeat; fever; mental or mood changes; severe headache; stomach pain; tremor; uncontrolled speech or muscle movements (eg, tics); unusual weakness or tiredness; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include aggressiveness; coma; confusion; depression; fast breathing; fatigue; fever; hallucinations; increased reflexes; irregular heartbeat; muscle pain; panic; restlessness; seizures; severe dizziness; severe or persistent nausea, vomiting, or diarrhea; stomach pain; tremor.

Proper storage of Dexedrine :

Store Dexedrine at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Keep in a tightly closed container. Do not store in the bathroom. Keep Dexedrine out of the reach of children and away from pets.

General information:

  • If you have any questions about Dexedrine , please talk with your doctor, pharmacist, or other health care provider.
  • Dexedrine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Dexedrine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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