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All about: Donnatal Extentabs Controlled-Release Tablets

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Generic Name: Belladonna Alkaloids/Phenobarbital Controlled-Release Tablets (bell-a-DON-a/fee-noe-BAR-bih-tal)
Brand Name: Examples include Alkabel-SR and Donnatal Extentabs

Donnatal Extentabs Controlled-Release Tablets is used for:

Treating irritable bowel syndrome and intestinal inflammation in combination with other medicines. It may also be used along with other medicines to treat intestinal ulcers. It may also be used for other conditions as determined by your doctor.

Donnatal Extentabs Controlled-Release Tablets is an anticholinergic and barbiturate combination. It works by decreasing the motion of the muscles in the stomach and intestine and providing mild sedation.

Do NOT use Donnatal Extentabs Controlled-Release Tablets if:

  • you are allergic to any ingredient in Donnatal Extentabs Controlled-Release Tablets
  • you have previously experienced restlessness or excitement after taking phenobarbital
  • you have glaucoma; severe irritation of the esophagus or other serious problems with the esophagus (eg, esophageal achalasia); a blockage of the stomach, bowel, or bladder; bowel motility problems; severe bowel inflammation (eg, ulcerative colitis); certain muscle problems (eg, myasthenia gravis); or heart problems with severe bleeding
  • you have a history of the blood disorder porphyria
  • you have a history of alcohol or substance abuse or dependence or may be at risk for an addiction
  • you are taking methoxyflurane, sodium oxybate (GHB), or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Donnatal Extentabs Controlled-Release Tablets:

Some medical conditions may interact with Donnatal Extentabs Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have nerve problems, prostate problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, diarrhea, fever, risk factors for glaucoma, kidney or liver problems, gallbladder problems, lung or breathing problems, an overactive thyroid, high blood pressure, difficulty urinating, or ulcer
  • if you have depression, pain, a history of suicidal thoughts or attempts, or are in shock
  • if you have been very ill or severely weakened
  • if you regularly consume alcohol

Some MEDICINES MAY INTERACT with Donnatal Extentabs Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase (MAO) inhibitors (eg, phenelzine), phenothiazines (eg, thioridazine), quinine, stiripentol, tricyclic antidepressants (eg, amitriptyline), valproic acid, or other anticholinergics (eg, scopolamine) because they may increase the risk of Donnatal Extentabs Controlled-Release Tablets's side effects
  • Methoxyflurane orsodium oxybate (GHB) because the risk of their side effects may be increased by Donnatal Extentabs Controlled-Release Tablets
  • Anticoagulants (eg, warfarin), beta-blockers (eg, propranolol), clozapine, corticosteroids (eg, hydrocortisone), cyclosporine, doxorubicin, doxycycline, erlotinib, estrogens (eg, estradiol), imatinib, metronidazole, quinidine, steroidal contraceptives (eg, birth control pills), theophylline, or voriconazole because their effectiveness may be decreased by Donnatal Extentabs Controlled-Release Tablets
  • Halothane because Donnatal Extentabs Controlled-Release Tablets may mask the symptoms of halothane toxicity

This may not be a complete list of all interactions that may occur. Ask your health care provider if Donnatal Extentabs Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Donnatal Extentabs Controlled-Release Tablets:

Use Donnatal Extentabs Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Donnatal Extentabs Controlled-Release Tablets by mouth with or without food.
  • Swallow Donnatal Extentabs Controlled-Release Tablets whole. Do not break, crush, or chew before swallowing.
  • If you miss a dose of Donnatal Extentabs Controlled-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Donnatal Extentabs Controlled-Release Tablets.

Important safety information:

  • Donnatal Extentabs Controlled-Release Tablets may cause dizziness, drowsiness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Donnatal Extentabs Controlled-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Donnatal Extentabs Controlled-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.
  • Donnatal Extentabs Controlled-Release Tablets may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • Use Donnatal Extentabs Controlled-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially excitement, agitation, or drowsiness.
  • Donnatal Extentabs Controlled-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Donnatal Extentabs Controlled-Release Tablets. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • PREGNANCY and BREAST-FEEDING: Donnatal Extentabs Controlled-Release Tablets has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Donnatal Extentabs Controlled-Release Tablets while you are pregnant. Donnatal Extentabs Controlled-Release Tablets is found in breast milk. If you are or will be breast-feeding while you use Donnatal Extentabs Controlled-Release Tablets, check with your doctor. Discuss any possible risks to your baby.

When used for long periods of time or at high doses, this medicine may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Donnatal Extentabs Controlled-Release Tablets stops working well. Do not take more than prescribed.

Some people who use Donnatal Extentabs Controlled-Release Tablets for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking Donnatal Extentabs Controlled-Release Tablets suddenly, you may have WITHDRAWAL symptoms. These may include anxiety, nausea, sleeplessness, body aches, seizures, and delirium.

Possible side effects of Donnatal Extentabs Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; clumsiness; constipation; decreased sweating; dizziness; drowsiness; dry mouth; excessive daytime drowsiness ("hangover effect"); feeling of a whirling motion; headache; lightheadedness; nausea; nervousness; tired feeling; trouble sleeping.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; confusion; diarrhea; difficulty focusing eyes; disorientation; exaggerated feeling of well-being; excitement; fainting; fast or irregular heartbeat; hallucinations; loss of coordination; loss of taste; memory loss; muscle pain; pounding in the chest; severe or persistent trouble sleeping; trouble urinating; unusual weakness; very slow breathing; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include change in size of pupil; deep sleep; hot, dry skin; loss of consciousness; severe dry mouth; severe or persistent headache or nausea; slowed or fast breathing; trouble swallowing; vomiting.

Proper storage of Donnatal Extentabs Controlled-Release Tablets:

Store Donnatal Extentabs Controlled-Release Tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Donnatal Extentabs Controlled-Release Tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Donnatal Extentabs Controlled-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Donnatal Extentabs Controlled-Release Tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Donnatal Extentabs Controlled-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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