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All about: Dyazide

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Generic Name: Triamterene/Hydrochlorothiazide Capsules and Tablets (trye-AM-ter-een/hye-droe-klor-oh-THYE-a-zide)
Brand Name: Examples include Dyazide and Maxzide

Dyazide can increase potassium levels in your body. This is more likely to occur in elderly patients, patients who are severely ill, or patients with kidney problems and diabetes. If not treated, high potassium levels can be fatal. Potassium levels must be closely monitored in people with any of these problems or illnesses. Lab tests will be required so be sure to keep appointments. If you develop muscle weakness or an unusual heart beat, notify your doctor immediately.


Dyazide is used for:

Treating fluid retention (edema) and high blood pressure. It may be used alone or with other medicines. It may also be used to treat other conditions as determined by your doctor.

Dyazide is a diuretic (water pill) and is a combination of a potassium-sparing diuretic (triamterene) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The triamterene component helps minimize potassium loss.

Do NOT use Dyazide if:

  • you are allergic to any ingredient in Dyazide or any other sulfonamide (eg, sulfamethoxazole)
  • you are unable to urinate, have severe kidney problems, or high blood potassium
  • you are taking other potassium-sparing diuretics (eg, spironolactone), salt substitutes containing potassium, or dofetilide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dyazide :

Some medical conditions may interact with Dyazide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, or systemic lupus erythematosus (SLE or lupus)
  • if you have dehydration, elevated blood acid, low folic acid levels, or electrolyte problems

Some MEDICINES MAY INTERACT with Dyazide . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Potassium sparing diuretics (eg, spironolactone), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because the effectiveness of Dyazide may be decreased and the risk of kidney problems may be increased
  • Certain chemotherapy medicines or dofetilide because the risk of serious side effects may be increased by Dyazide
  • Diazoxide, lithium, or nondepolarizing neuromuscular blockers (eg, pancuronium) because the actions and side effects may be increased by Dyazide
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of high blood potassium and kidney problems may be increased by Dyazide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dyazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dyazide :

Use Dyazide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Dyazide by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Dyazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • If you miss a dose of Dyazide , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dyazide .

Important safety information:

  • Dyazide may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Dyazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Dyazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Dyazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Dyazide . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Dyazide before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Dyazide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • LAB TESTS, including liver function, kidney function, lung function, blood pressure, and fasting blood glucose, may be performed while you use Dyazide . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Dyazide should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dyazide while you are pregnant. Dyazide is found in breast milk. Do not breast-feed while taking Dyazide .

Possible side effects of Dyazide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in blood sugar; constipation; dizziness; fatigue; headache; inflammation of a salivary gland; loss of appetite; nausea; sensitivity to sunlight; stomach pain; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dry mouth; excessive thirst; impotence; leg or muscle cramps; mental confusion; rapid, weak, or irregular heartbeat; stomach pain; urination problems; vomiting; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include excessive urination; flushed face; lightheadedness especially upon standing; nausea; vomiting; weakness.

Proper storage of Dyazide :

Store Dyazide at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep this medicine out of the reach of children and away from pets.

General information:

  • If you have any questions about Dyazide , please talk with your doctor, pharmacist, or other health care provider.
  • Dyazide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Dyazide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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