17 . July , 2018 - Tuesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Dyphylline

Big Image Pronouncation: (DIE-fih-lin)
Class: Xanthine derivative

Trade Names:
- Tablets 200 mg
- Tablets 400 mg

Trade Names:
- Elixir 100 mg per 15 mL

Mechanism of Action


Relaxes bronchial smooth muscle and stimulates central respiratory drive.



Rapidly absorbed, reaching a mean C max of 17.1 mcg/mL in about 45 min.


Not metabolized.


Unchanged by the kidney. Elimination t ½ is approximately 2 h.

Indications and Usage

Relief of acute bronchial asthma and reversible bronchospasm associated with chronic bronchitis and emphysema.


Hypersensitivity to any component of the product or related xanthine compounds.

Dosage and Administration


PO Usual dose up to 15 mg/kg every 6 h. Elixir: 200 to 400 mg (2 to 4 Tbsp) every 6 h. Dose should be titrated to severity of condition and response of patient. Measure and administer prescribed dose of elixir using dosing syringe, dosing spoon, or dosing cup.


Store tablets and elixir at controlled room temperature (59° to 86°F). Store Lufyllin tablets between 68° and 77°F.

Drug Interactions


May increase the plasma t ½ of dyphylline.

Sympathomimetic bronchodilators

Synergistic pharmacologic effect may occur.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Circulatory failure; extrasystoles; flushing; hypotension; palpitation; tachycardia; ventricular arrhythmias.


Agitation; CNS stimulation; generalized clonic and tonic convulsions; headache; hyperexcitability; insomnia; irritability; muscle twitching; restlessness.


Diarrhea; epigastric pain; hematemesis; nausea; vomiting.


Dehydration; hyperglycemia; inappropriate antidiuretic hormone syndrome.


Albuminuria; diuresis; gross and microscopic hematuria; increased excretion of renal tubule and red blood cells.


Respiratory arrest; tachypnea.





Note frequency and severity of asthma attacks.


Category C .


Excreted in breast milk.


Safety and efficacy have not been established.


Use with caution (usually starting at the low end of the dosage range) because of the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant diseases or other drug therapy.

Renal Function

Cl is reduced in patients with impaired renal function; make appropriate dosage adjustments.

Special Risk Patients

Use with caution in patients with severe cardiac disease, hypertension, hyperthyroidism, acute myocardial injury, or peptic ulcer.

Xanthine products

Ensure other xanthine products (eg, theophylline) are not being administered concurrently with dyphylline.



Agitation, anorexia, cardiac arrhythmias, CV collapse, death, dehydration, diaphoresis, diarrhea, excessive thirst, extrasystoles, fasciculation, generalized clonic and tonic convulsions, headache, hyperreflexia, hyperthermia, insomnia, irritability, nausea, nervousness, restlessness, seizures, severe vomiting, tachycardia, tinnitus, vomiting.

Patient Information

  • Advise patient to take prescribed dose every 6 h without regard to meals but to take with food if stomach upset occurs.
  • Advise patient or caregiver using elixir to measure and administer prescribed dose using dosing syringe, dosing spoon, or dosing cup.
  • Advise patient if a dose is missed to take the dose as soon as remembered. However, if it is less than 3 h before the next scheduled dose, advise patient to skip the missed dose and take the next dose at the regularly scheduled time. Caution patient not to double the dose to catch up.
  • Instruct patient not to stop the medication once symptoms have been controlled and that continued daily use is necessary to continue to control symptoms.
  • Advise patient not to change the dose or stop using unless advised by health care provider.
  • Advise patient that medication does not replace controller medications (eg, inhaled or oral corticosteroids) and to continue daily use of controller medications as prescribed by health care provider.
  • Caution patient not to increase dose and to inform health care provider if asthma symptoms do not improve or worsen, if a more short-acting bronchodilator than usual is needed, or if the short-acting bronchodilator appears to become less effective.
  • Advise patient to carry medical identification (eg, card, bracelet) if experiencing acute severe asthma attacks requiring rapid systemic treatment.
  • Advise patient or caregiver to promptly report any of the following to health care provider: anxiety, nervousness, or restlessness; persistent nausea, vomiting, or diarrhea; fainting spells or lightheadedness; fast or irregular heartbeat; pounding in the chest; flushing of the face; seizures (convulsions); skin rash, itching, or hives; tremor; unusual weakness or tiredness.

Recent Drug Updates at DrugIndexOnline:

Acetaminophen, Aspirin, and Caffeine Acetaminophen, Aspirin, and Caffeine
Some commonly used brand names are: In the U.S.— Excedrin Extra-Strength Caplets 1 Excedrin Extra-Strength Tablets 1 Excedrin Migraine 1 Gelpirin 2 Goody's Fast Pain Relief 1 Goody's Headache Powders 1 Rid-A-Pain Compound 4 Saleto 3 Supac 2 Vanquish Caplets 2 Note: In Canada, Excedr more...

Aquaderm Sunscreen Moisturizer Topical Aquaderm Sunscreen Moisturizer Topical
Some commonly used brand names are: In the U.S.— A-Fil 33 Aquaderm Sunscreen Moisturizer 49 Aquaray Sunscreen 42 Bain de Soleil All Day For Kids 38 Bain de Soleil All Day Sunfilter 39 Bain de Soleil Mega Tan 34 Bain de Soleil Orange Gelee 41 Bain de Soleil Sand Buster 41 Bain de Soleil SP more...

Diazoxide, Parenteral Diazoxide, Parenteral
Pronouncation: (DIE-aze-OX-ide) Class: Agent for hypertensive emergencies Trade Names: Hyperstat IV - Injection 15 mg/mL Mechanism of Action Pharmacology Relaxes smooth muscle in peripheral arterioles, thus reducing BP. Pharmacokinetics Distribution Greater than 90% protein bound. Crosses placenta. more...

hydrochlorothiazide and benazepril hydrochlorothiazide and benazepril
Generic Name: hydrochlorothiazide and benazepril (hye droe klor oh THYE a zide and beh NAY zah prill) Brand Names: Lotensin HCT What is hydrochlorothiazide and benazepril? Hydrochlorothiazide is a thiazide diuretic (water pill). It increases the amount of salt and water you lose in your more...

Livitrinsic-F Livitrinsic-F
Generic Name: multivitamins with iron (mull tee VYE tah mins with i ron) Brand Names: Allbee-C 800 with Iron, Anemagen, Anemagen FA, Bugs Bunny with Iron Chewable, Chromatinic, Contrin, Dayalets Plus Iron, Diatx Fe, Equi-Roca Plus, Equicyte Plus, Fe-Tinic 150 Forte, Femiron Multi with Iro more...

Norvir Solution Norvir Solution
Generic Name: Ritonavir Oral Solution (ri-TOE-na-veer) Brand Name: NorvirUse of ritonavir with certain nonsedating antihistamines (eg, astemizole, terfenadine), sedatives and tranquilizers (eg, midazolam, triazolam), heart medicines (antiarrhythmics such as bepridil, flecainide, propafenone, qui more...

Poly-Pred Suspension Poly-Pred Suspension
Generic Name: neomycin/polymyxin B/prednisolone ophthalmic (nee oh MY sin/paw lee MIX in/pred NISS oh lone) Brand Names: Poly-Pred Suspension What is Poly-Pred Suspension (neomycin/polymyxin B/prednisolone ophthalmic)? Neomycin and polymyxin B are antibiotics. They are used to treat bac more...

Potassium Iodide Syrup Potassium Iodide Syrup
Generic Name: Potassium Iodide Syrup (poe-TASS-ee-uhm EYE-oh-dide) Brand Name: PimaPotassium Iodide Syrup is used for:Treating lung conditions or disease in which mucus complicates the condition (eg, emphysema, bronchial asthma, bronchitis). It may also be used for other conditions as determined more...