15 . February , 2019 - Friday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Edetate Disodium (EDTA)

Big Image ( EDTA ) Pronouncation: (EH-duh-tate die-SO-dee-uhm)
Class: Cardiovascular agent

Trade Names:
Endrate
- Injection 150 mg/mL

Mechanism of Action

Pharmacology

Forms chelates with polyvalent metals, especially calcium, thus increasing their urinary excretion.

Pharmacokinetics

Elimination

The chelate formed is excreted in the urine.

Indications and Usage

Emergency treatment of hypercalcemia; control of ventricular arrhythmias associated with digitalis toxicity.

Contraindications

Anuria.

Dosage and Administration

Adults

IV 50 mg/kg/day (max 3 g/day). Usually administered in 5 consecutive daily doses followed by 2 days without medication, with repeated courses as needed, for total of 15 doses.

Dissolve 50 mg/kg dose in 500 mL of D5W or sodium chloride 0.9% for injection. Infuse over 3 h or more.

Children

IV 40 mg/kg/day (max 70 mg/kg/day) or 15 to 50 mg/kg/day (max 3 g/day) with 5 days between courses.

Dissolve drug in sufficient volume of D5W or sodium chloride 0.9% for injection to bring final concentration to 3% or less. Infuse over 3 h or more.

General Advice

Do not confuse edetate disodium with edetate calcium disodium.

Storage/Stability

Store at room temperature.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Transient drop in BP; adverse reactions on myocardial contractility; thrombophlebitis.

CNS

Transient circumoral paresthesia; numbness; headache.

Dermatologic

Exfoliative dermatitis; toxic skin and mucous membrane reactions.

GI

Nausea; vomiting; diarrhea.

Genitourinary

Nephrotoxicity; damage to reticuloendothelial system.

Hematologic

Thrombophlebitis; anemia.

Metabolic

Electrolyte imbalances including hypocalcemia, hypokalemia, and hypomagnesemia; hyperuricemia.

Miscellaneous

Febrile reactions.

Precautions

Monitor

Hypocalcemia

If signs or symptoms of hypocalcemia occur (eg, circumoral numbness/tingling, positive Chvostek's or Trousseau's signs, tetany), notify health care provider.


Pregnancy

Category C .

Lactation

Undetermined.

Special Risk Patients

Use drug cautiously in patients with limited cardiac reserve or incipient congestive failure.

Diabetic patients

Blood sugar and insulin requirements may be lower in insulin-dependent diabetic patients.

Hydration

Adequately hydrate patient before administration.

IV infusion

Rapid IV infusion or high serum concentrations can cause a precipitous and potentially fatal drop in serum calcium. Do not exceed maximum dose or rate.

Overdosage

Symptoms

Drop in serum calcium.

Patient Information

  • Advise patient to remain recumbent for 30 min after infusion because of possibility of orthostatic hypotension.
  • Inform patient that breath may be odorous.

Recent Drug Updates at DrugIndexOnline:





acetaminophen/ chlorpheniramine/ dextromethorphan/ phenylpropanolamine acetaminophen/ chlorpheniramine/ dextromethorphan/ phenylpropanolamine
Generic Name: acetaminophen/ chlorpheniramine/ dextromethorphan/ phenylpropanolamine (a seet a MIN oh fen/klor fen IR a meen/dex troe meth OR fan/fen ill proe pa NOLE a meen) Brand Names: Comtrex Cold and Flu Maximum Strength, Comtrex Maximum Strength Cold Relief, Contac Severe Cold and F more...

Brompheniramine, Phenylephrine, Hydrocodone, and Guaifenesin Brompheniramine, Phenylephrine, Hydrocodone, and Guaifenesin
Some commonly used brand names are: In the U.S.— Alka-Seltzer Plus Cold and Cough 21 Alka-Seltzer Plus Cold and Cough Medicine Liqui-Gels 34 Alka-Seltzer Plus Night-Time Cold Liqui-Gels 35 Ami-Tex LA 69 Anatuss LA 70 Benylin Expectorant 54 Bromfed-DM 17 Broncholate 68 Carbinoxamine Compou more...

Cutivate Cream Cutivate Cream
Generic Name: Fluticasone Cream and Ointment (flue-TIK-a-sone) Brand Name: CutivateCutivate Cream is used for:Treating itching and redness of many skin conditions. Cutivate Cream is a topical corticosteroid that is thought to work by reducing the amount of a chemical in the body that causes infl more...

Doan's Pills Doan's Pills
Generic Name: Magnesium Salicylate (mag-NEE-zee-uhm sal-i-SIL-ate) Brand Name: Examples include Doan's Pills and DeWilt's Pain RelieverDoan's Pills is used for:Treating minor backache pain. It may also be used for other conditions as determined by your doctor. Doan's Pills is a nonsteroidal a more...

Dynabac Dynabac
Generic Name: dirithromycin (dir ith roe MYE sin) Brand Names: Dynabac What is Dynabac (dirithromycin)? Dirithromycin is in a class of drugs called macrolide antibiotics. Dirithromycin fights bacteria in your body. Dirithromycin is used to treat many different types of bacterial infecti more...

Hydrocil Hydrocil
Generic Name: psyllium (SIH lee um) Brand Names: Alramucil, Cilium, Fiber Eze, Fiberall, Genfiber, Hydrocil, Konsyl, Konsyl for Kids, Konsyl-D, Konsyl-Orange, Maalox Daily Fiber Therapy, Metamucil, Modane Bulk, Perdiem Fiber, Reguloid, Serutan, Syllact, V-Lax What is Hydrocil (psyllium)? more...

Keralac Cream Keralac Cream
Generic Name: Urea Cream, Gel, and Ointment 25%, 30%, 40%, and 50% (you-REE-ah) Brand Name: Examples include Carmol-40 and KeralacKeralac Cream is used for:Promoting the healing of certain skin conditions (eg, hyperkeratotic conditions). It may also be used for certain other skin conditions (eg more...

Mycamine Mycamine
Generic Name: Micafungin (mi-ka-FUN-gin) Brand Name: MycamineMycamine is used for:Treating fungal infections of the esophagus. It is also used to prevent fungal infections in patients undergoing stem cell transplantation. Mycamine is an antifungal agent. It works by interfering with the format more...