18 . August , 2018 - Saturday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Edetate Disodium (EDTA)

Big Image ( EDTA ) Pronouncation: (EH-duh-tate die-SO-dee-uhm)
Class: Cardiovascular agent

Trade Names:
- Injection 150 mg/mL

Mechanism of Action


Forms chelates with polyvalent metals, especially calcium, thus increasing their urinary excretion.



The chelate formed is excreted in the urine.

Indications and Usage

Emergency treatment of hypercalcemia; control of ventricular arrhythmias associated with digitalis toxicity.



Dosage and Administration


IV 50 mg/kg/day (max 3 g/day). Usually administered in 5 consecutive daily doses followed by 2 days without medication, with repeated courses as needed, for total of 15 doses.

Dissolve 50 mg/kg dose in 500 mL of D5W or sodium chloride 0.9% for injection. Infuse over 3 h or more.


IV 40 mg/kg/day (max 70 mg/kg/day) or 15 to 50 mg/kg/day (max 3 g/day) with 5 days between courses.

Dissolve drug in sufficient volume of D5W or sodium chloride 0.9% for injection to bring final concentration to 3% or less. Infuse over 3 h or more.

General Advice

Do not confuse edetate disodium with edetate calcium disodium.


Store at room temperature.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Transient drop in BP; adverse reactions on myocardial contractility; thrombophlebitis.


Transient circumoral paresthesia; numbness; headache.


Exfoliative dermatitis; toxic skin and mucous membrane reactions.


Nausea; vomiting; diarrhea.


Nephrotoxicity; damage to reticuloendothelial system.


Thrombophlebitis; anemia.


Electrolyte imbalances including hypocalcemia, hypokalemia, and hypomagnesemia; hyperuricemia.


Febrile reactions.




If signs or symptoms of hypocalcemia occur (eg, circumoral numbness/tingling, positive Chvostek's or Trousseau's signs, tetany), notify health care provider.


Category C .



Special Risk Patients

Use drug cautiously in patients with limited cardiac reserve or incipient congestive failure.

Diabetic patients

Blood sugar and insulin requirements may be lower in insulin-dependent diabetic patients.


Adequately hydrate patient before administration.

IV infusion

Rapid IV infusion or high serum concentrations can cause a precipitous and potentially fatal drop in serum calcium. Do not exceed maximum dose or rate.



Drop in serum calcium.

Patient Information

  • Advise patient to remain recumbent for 30 min after infusion because of possibility of orthostatic hypotension.
  • Inform patient that breath may be odorous.

Recent Drug Updates at DrugIndexOnline:

Aminosyn II Injection Hospira Aminosyn II Injection Hospira
Dosage Form: Injection hospira NOTE: These solutions are hypertonic. See WARNINGS and PRECAUTIONS. Nutrimix® Dual-chamber Flexible Container The Upper Chamber Contains 500 mL of Aminosyn II 7% (An Amino Acid Injection) The Lower Chamber Contains 500 mL of 10% Dextrose Injection, USP Rx only more...

Ethosuximide Ethosuximide
Generic Name: Ethosuximide Dosage Form: Capsules, usp Ethosuximide DescriptionEthosuximide is an anticonvulsant succinimide, chemically designated as alpha-ethyl-alpha-methyl-succinimide, with the following structural formula: Each Ethosuximide capsule for oral administration contains more...

Fluviral S/F Fluviral S/F
Some commonly used brand names are: In the U.S.— FluMist FluShield Fluvirin Fluzone In Canada— Fluviral Fluviral S/F Fluzone Generic name product may be available in the U.S. Another commonly used name is flu vaccine . Category Immunizing agent, active Description Influen more...

Humulin N Suspension Humulin N Suspension
Generic Name: Insulin Isophane (Human Origin) Suspension (IN-su-lin) Brand Name: Examples include Humulin N and Novolin NAny change of insulin should be made cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (regular, NPH, lente), species (be more...

Klotrix Klotrix
Some commonly used brand names are: In the U.S.— Cena-K 5 Effer-K 4 Gen-K 5 Glu-K 6 K-8 5 K+ 10 5 Kaochlor 10% 5 Kaochlor S-F 10% 5 Kaon 6 Kaon-Cl 5 Kaon-Cl-10 5 Kaon-Cl 20% Liquid 5 Kato 5 Kay Ciel 5 Kaylixir 6 K+ Care 5 K+ Care ET 2 K-Dur 5 K-Electrolyte 2 K-G Elixir 6 K-Ide 3 K-Lease 5 more...

Medi-Sleep Medi-Sleep
Generic Name: Doxylamine (Sleep Aid) (dox-IL-a-meen) Brand Name: Examples include Medi-Sleep and UnisomMedi-Sleep is used for:Treating occasional sleeplessness and reducing difficulty falling asleep. Medi-Sleep is an antihistamine. It works by depressing the central nervous system (brain) to more...

Mifepristone Mifepristone
Some commonly used brand names are: In the U.S.— Mifeprex Other commonly used names are RU 486 Category Abortifacient Description Mifepristone (mif-i-PRIS-tone)is used to end a pregnancy that is less than 49 days in duration. It works by stopping the supply of hormones that mainta more...

Nicorette oral/patches/nasal Nicorette oral/patches/nasal
Generic Name: nicotine (oral/patches/nasal) (NICK oh teen) Brand Names: Commit, Habitrol, Nicoderm C-Q, Nicorette, Nicorette DS, Nicotrol, Nicotrol Inhaler, Nicotrol NS What is nicotine? Nicotine is the primary ingredient in tobacco products. Nicotine in medical products is used to aid i more...