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All about: Edetate Disodium (EDTA)

Big Image ( EDTA ) Pronouncation: (EH-duh-tate die-SO-dee-uhm)
Class: Cardiovascular agent

Trade Names:
- Injection 150 mg/mL

Mechanism of Action


Forms chelates with polyvalent metals, especially calcium, thus increasing their urinary excretion.



The chelate formed is excreted in the urine.

Indications and Usage

Emergency treatment of hypercalcemia; control of ventricular arrhythmias associated with digitalis toxicity.



Dosage and Administration


IV 50 mg/kg/day (max 3 g/day). Usually administered in 5 consecutive daily doses followed by 2 days without medication, with repeated courses as needed, for total of 15 doses.

Dissolve 50 mg/kg dose in 500 mL of D5W or sodium chloride 0.9% for injection. Infuse over 3 h or more.


IV 40 mg/kg/day (max 70 mg/kg/day) or 15 to 50 mg/kg/day (max 3 g/day) with 5 days between courses.

Dissolve drug in sufficient volume of D5W or sodium chloride 0.9% for injection to bring final concentration to 3% or less. Infuse over 3 h or more.

General Advice

Do not confuse edetate disodium with edetate calcium disodium.


Store at room temperature.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Transient drop in BP; adverse reactions on myocardial contractility; thrombophlebitis.


Transient circumoral paresthesia; numbness; headache.


Exfoliative dermatitis; toxic skin and mucous membrane reactions.


Nausea; vomiting; diarrhea.


Nephrotoxicity; damage to reticuloendothelial system.


Thrombophlebitis; anemia.


Electrolyte imbalances including hypocalcemia, hypokalemia, and hypomagnesemia; hyperuricemia.


Febrile reactions.




If signs or symptoms of hypocalcemia occur (eg, circumoral numbness/tingling, positive Chvostek's or Trousseau's signs, tetany), notify health care provider.


Category C .



Special Risk Patients

Use drug cautiously in patients with limited cardiac reserve or incipient congestive failure.

Diabetic patients

Blood sugar and insulin requirements may be lower in insulin-dependent diabetic patients.


Adequately hydrate patient before administration.

IV infusion

Rapid IV infusion or high serum concentrations can cause a precipitous and potentially fatal drop in serum calcium. Do not exceed maximum dose or rate.



Drop in serum calcium.

Patient Information

  • Advise patient to remain recumbent for 30 min after infusion because of possibility of orthostatic hypotension.
  • Inform patient that breath may be odorous.

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